Results 61 to 70 of about 7,638,076 (261)

Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer’s disease pathology in the population?

Alzheimer’s Research & Therapy
Background White matter hyperintensities (WMH) are considered hallmark features of cerebral small vessel disease and have recently been linked to Alzheimer’s disease (AD) pathology. Their distinct spatial distributions, namely periventricular versus deep
Aishwarya Pradeep, Sheelakumari Raghavan, Scott A. Przybelski, Gregory M. Preboske, Christopher G. Schwarz, Val J. Lowe, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Jonathan Graff-Radford, Petrice M. Cogswell, Prashanthi Vemuri   +11 more
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Early diagnosis of Alzheimer's disease based on brain morphological changes: A comprehensive approach combining voxel-based morphometry and deep learning

NeuroImage: Reports
Deep learning algorithms optimize data by enhancing resolution and suppressing noise associated with biological knowledge. The root issue is that, for example, CNNs learning mathematical patterns from statistical correlations in the data without regard ...
Mohammad Rezaei, Shaghayegh Mohammadikhaveh, Hadis Faraji, Ramin Ardalani, Mina Rezaei, Alireza Shirazinodeh   +5 more
doaj   +1 more source

Deep Medullary Vein and MRI Markers Were Related to Cerebral Hemorrhage Subtypes

Brain Sciences, 2023
Background: To explore the performance of deep medullary vein (DMV) and magnetic resonance imaging (MRI) markers in different intracerebral hemorrhage (ICH) subtypes in patients with cerebral small vessel disease (CSVD).
Dan Wang, Yayun Xiang, Yuling Peng, Peng Zeng, Bang Zeng, Ying Chai, Yongmei Li   +6 more
doaj   +1 more source

White matter microstructural abnormalities in euthymic bipolar disorder

, 2010
Background: Abnormal diffusion parameters are reported in specific brain regions and white matter tracts in bipolar disorder. Aims: To investigate whether these abnormalities are generalised, and thus evident in large regions of white matter.
Gallagher, Peter, Ferrier, I Nicol, Marshall, Ian, Lloyd, Adrian J., Lloyd, Adrian J, Ferrier, I. Nicol, Moore, P Brian, Eyre, Rachel, Vasudev, Kamini, Wardlaw, Joanna M, Moore, P. Brian, Bastin, Mark E., Young, Allan H; id_orcid, Macritchie, Karine A N, Young, Allan H., Wardlaw, Joanna M., Bastin, Mark E   +16 more
core   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Distinct Spatiotemporal Patterns of White Matter Hyperintensity Progression [PDF]

White matter hyperintensity, a key imaging biomarker for brain health, has prognostic implications for stroke. Using a multicenter MRI dataset of 9179 stroke patients plus the UK Biobank (n = 36,210 low/high risk controls), we employ Subtype and Stage ...
Hong, Keun-Sik, Yu, Kyung-Ho, Lee, Jun, Lee, Byung-Chul, Bae, Hee-Joon, Park, Gilsoon, Schellingerhout, Dawid, Park, Sang-Soon, Park, Jong-Moo, Kim, Hosung, Bath, Philip M, Lee, Soo Joo, Choi, Kang-Ho, Kim, Beom Joon, Haddad, Elizabeth, Chung, Jinyong, Jahanshad, Neda, Kang, Kyusik, Kim, Jae Guk, Cho, Yong-Jin, Oh, Hyerin, Kim, Joon-Tae, Park, Man Seok, Oh, Mi Sun, Gwak, Dong Seok, Gwak, Dong-Seok, Jeong, Sang-Wuk, Han, Moon-Ku, Bath, Philip M., Lee, Kyungbok, Wardlaw, Joanna M, Kim, Dong-Eog, Kim, Hang-Rai, Park, Tai Hwan, Wardlaw, Joanna M., Cha, Jae-Kwan, Kim, Dae-Hyun, Ryu, Wi-Sun   +37 more
core   +1 more source

Ofatumumab Therapy and Long‐Term Seizure Outcomes of Patients With Relapsing Anti‐NMDA Receptor Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley   +1 more source

End-to-end volumetric segmentation of white matter hyperintensities using deep learning

Computer Methods and Programs in Biomedicine
Reliable detection of white matter hyperintensities (WMH) is crucial for studying the impact of diffuse white-matter pathology on brain health and monitoring changes in WMH load over time. However, manual annotation of 3D high-dimensional neuroimages is laborious and can be prone to biases and errors in the annotation procedure.
Sadaf Farkhani, Naiara Demnitz, Carl-Johan Boraxbekk, Henrik Lundell, Hartwig Roman Siebner, Esben Thade Petersen, Kristoffer Hougaard Madsen   +6 more
openaire   +6 more sources

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source