Results 91 to 100 of about 716,083 (340)

Loss of brain inter-frequency hubs in Alzheimer's disease [PDF]

, 2017
Alzheimer's disease (AD) causes alterations of brain network structure and function. The latter consists of connectivity changes between oscillatory processes at different frequency channels. We proposed a multi-layer network approach to analyze multiple-
Attal, Yohan, Chavez, Mario, Colliot, Olivier, Dubois, Bruno, Fallani, Fabrizio De Vico, Guillon, Jeremy, La Corte, Valentina, Schwartz, Denis   +7 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Topology of brain functional connectivity networks in posttraumatic stress disorder

Data in Brief, 2018
Here we present functional neuroimaging-based network data (focused on the default mode network) collected from a cohort of US Veterans with history of combat exposure, combined with clinical assessments for PTSD and other psychiatric comorbidities.
Teddy J. Akiki, Christopher L. Averill, Kristen M. Wrocklage, J. Cobb Scott, Lynnette A. Averill, Brian Schweinsburg, Aaron Alexander-Bloch, Brenda Martini, Steven M. Southwick, John H. Krystal, Chadi G. Abdallah   +10 more
doaj   +1 more source

Platelet serotonin transporter function predicts default-mode network activity. [PDF]

PLoS ONE, 2014
The serotonin transporter (5-HTT) is abundantly expressed in humans by the serotonin transporter gene SLC6A4 and removes serotonin (5-HT) from extracellular space.
Christian Scharinger, Ulrich Rabl, Christian H Kasess, Bernhard M Meyer, Tina Hofmaier, Kersten Diers, Lucie Bartova, Gerald Pail, Wolfgang Huf, Zeljko Uzelac, Beate Hartinger, Klaudius Kalcher, Thomas Perkmann, Helmuth Haslacher, Andreas Meyer-Lindenberg, Siegfried Kasper, Michael Freissmuth, Christian Windischberger, Matthäus Willeit, Rupert Lanzenberger, Harald Esterbauer, Burkhard Brocke, Ewald Moser, Harald H Sitte, Lukas Pezawas   +24 more
doaj   +1 more source

A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis

Frontiers in Psychiatry, 2020
Recent studies have demonstrated substantial phenotypic overlap, notably social impairment, between autism spectrum disorder (ASD) and schizophrenia. However, the neural mechanisms underlying the pathogenesis of social impairments across these distinct ...
Aarti Nair, M. Jolliffe, Yong Seuk S. Lograsso, C. Bearden   +3 more
semanticscholar   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

Lifespan differences in background functional connectivity of core cognitive large-scale brain networks

Neuroscience Research
Large-scale brain networks undergo functional reorganization over the course of the lifespan, with concurrent implications for cognition. Characterizing network connectivity during a task may provide complementary insight into cognitive development and ...
Patrick J. Pruitt, Lingfei Tang, Jessica M. Hayes, Noa Ofen, Jessica S. Damoiseaux   +4 more
doaj   +1 more source

The Default Mode Network and Altered Consciousness in Epilepsy

Behavioural Neurology, 2011
The default mode network has been hypothesized based on the observation that specific regions of the brain are consistently activated during the resting state and deactivated during engagement with task. The primary nodes of this network, which typically
Nathan B. Danielson, Jennifer N. Guo, Hal Blumenfeld   +2 more
doaj   +1 more source

Functional Network-Based Statistics Reveal Abnormal Resting-State Functional Connectivity in Minimal Hepatic Encephalopathy

Frontiers in Neurology, 2019
Purpose: Whole-brain functional network analysis is an emerging methodology for exploring the mechanisms underlying hepatic encephalopathy (HE). This study aimed to identify the brain subnetwork that is significantly altered within the functional ...
Chuanyin Zhan, Hua-Jun Chen, Yong-Qing Gao, Tian-Xiu Zou   +3 more
doaj   +1 more source