Results 81 to 90 of about 1,007,015 (362)

Cholinergic Modulation of the Default Mode Like Network in Rats [PDF]

iScience, 2020
The discovery of the default mode network (DMN), a large-scale brain network that is suppressed during attention-demanding tasks, had major impact in neuroscience. This network exhibits an antagonistic relationship with attention-related networks. A better understanding of the processes underlying modulation of DMN is imperative, as this network is ...
Lore M. Peeters, Monica van den Berg, Rukun Hinz, Gaurav Majumdar, Isabel Pintelon, Georgios A. Keliris   +5 more
openaire   +5 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The sense of self in the aftermath of trauma: lessons from the default mode network in posttraumatic stress disorder

European Journal of Psychotraumatology, 2020
Trauma can profoundly affect the sense of self, where both cognitive and somatic disturbances to the sense of self are reported clinically by individuals with posttraumatic stress disorder (PTSD).
R. Lanius, Braeden A. Terpou, M. McKinnon   +2 more
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Altered Default Mode Network Dynamics in Civil Aviation Pilots

Frontiers in Neuroscience, 2020
BackgroundAirlines occupy an increasingly important place in the economy of many countries. Because air disasters may cause substantial losses, comprehensive surveys of the psychophysiological mechanism of flying are needed; however, relatively few ...
Xi Chen, Kaijun Xu, Yong Yang, Quanchuan Wang, Hao Jiang, Xiangmei Guo, Xipeng Chen, Jiazhong Yang, Cheng Luo   +8 more
doaj   +1 more source

Refugee visa insecurity disrupts the brain’s default mode network

European Journal of Psychotraumatology, 2023
Background: Research has largely focused on the psychological consequences of refugee trauma exposure, but refugees living with visa insecurity face an uncertain future that also adversely affects psychological functioning and self-determination ...
Belinda J. Liddell, Pritha Das, Gin S. Malhi, Angela Nickerson, Kim L. Felmingham, Mirjana Askovic, Jorge Aroche, Mariano Coello, Jessica Cheung, Miriam Den, Tim Outhred, Richard A. Bryant   +11 more
doaj   +1 more source

The Resolution Matrix for Visualizing Functional Network Connectivity [PDF]

arXiv, 2020
The resolution matrix is a mathematical tool for analyzing inverse problems such as computational imaging systems. When treating network connectivity estimation as an inverse problem, the resolution matrix describes the degree to which network nodes and edges can be resolved.
arxiv  

Long reaction times are associated with delayed brain activity in Lewy body dementia [PDF]

, 2018
A significant symptom of Lewy body dementia (LBD) is slow cognitive processing or bradyphrenia. In a previous fMRI task-based study, we found slower responses in LBD, accompanied by greater deactivation in the default mode network.
Firbank, MJ, O'Brien, JT, Taylor, JP
core   +1 more source

The role of default mode network in semantic cue integration [PDF]

NeuroImage, 2020
Recent accounts of large-scale cortical organisation suggest that the default mode network (DMN) is positioned at the top of a principal gradient, reflecting the separation between heteromodal and unimodal sensory-motor regions in patterns of connectivity and in geodesic distance along the cortical surface (Margulies et al., 2016).
Lanzoni, Lucilla, Ravasio, Daniela, Thompson, Hannah Elizabeth, Vatansever, Deniz, Margulies, Daniel S, Smallwood, Jonathan, Jefferies, Beth   +6 more
openaire   +4 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source