Results 71 to 80 of about 1,902,450 (297)

Energetics and kinetics of Li intercalation in irradiated graphene scaffolds

, 2015
In the present study we investigate the irradiation-defects hybridized graphene scaffold as one potential building material for the anode of Li-ion batteries.
Medhekar, N. V., Ouyang, B., Song, J.
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Molecular cytogenetic identification of small supernumerary marker chromosomes using chromosome microarray analysis

Molecular Cytogenetics, 2019
Background This study aimed to evaluate the feasibility of chromosomal microarray analysis (CMA) in detecting the origin and structure of small supernumerary marker chromosomes (sSMCs) in prenatal and postnatal cases and to clarify sSMC-related genotype ...
Huili Xue, Hailong Huang, Yan Wang, Gang An, Min Zhang, Liangpu Xu, Yuan Lin   +6 more
doaj   +1 more source

Localized D-dimensional global k-defects

, 2011
We explicitly demonstrate the existence of static global defect solutions of arbitrary dimensionality whose energy does not diverge at spatial infinity, by considering maximally symmetric solutions described by an action with non-standard kinetic terms ...
A. Achúcarro, A. Vilenkin, A.S. Goldhaber, C. Adam, C. Adam, C. Adam, C. Adam, C. Armendariz-Picon, C. Armendáriz-Picón, C.-Y. Hou, D. Bazeia, D. Bazeia, D. Bazeia, D. Bazeia, D. Bazeia, D. Bazeia, D.-J. Liu, D.P. Bennett, E. Babichev, E. Babichev, E. Babichev, E.N. Parker, G.H. Derrick, H. Watabe, I. Zlatev, J. Frieman, J. G. G. S. Ramos, J.H.P. Wu, J.J. Blanco-Pillado, K.A. Olive, L. Perivolaropoulos, L. Sousa, L. Sousa, M. Kalb, N. Bevis, N. Bose, P. P. Avelino, P.P. Avelino, P.P. Avelino, P.P. Avelino, P.P. Avelino, P.P. Avelino, P.P. Avelino, R. Jackiw, R. Menezes, R.H. Hobart, S. Coleman, S. Sarangi, S.H. Rhie, T. Goto, T. Skyrme, U. Pen, U.-L. Pen, V. Gorini, X.-h. Jin   +54 more
core   +1 more source

Defect formation from defect--anti-defect annihilations

, 2012
We show that when a topological defect with extended world-volume annihilates with an anti-defect, there arise topological defects with dimensions less than those of the original defects by one. Domain wall annihilations create vortices while monopole-string annihilations result in instantons.
openaire   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Clinical application of chromosomal microarray analysis in fetuses with increased nuchal translucency and normal karyotype

Molecular Genetics & Genomic Medicine, 2019
Background Submicroscopic chromosomal imbalance is associated with an increased nuchal translucency (NT). Most previous research has recommended the use of chromosomal microarray analysis (CMA) for prenatal diagnosis if the NT ≥ 3.5 mm. However, there is
Linjuan Su, Hailong Huang, Gang An, Meiying Cai, Xiaoqing Wu, Ying Li, Xiaorui Xie, Yuan Lin, Meiying Wang, Liangpu Xu   +9 more
doaj   +1 more source

Localized defects in a cellular automaton model for traffic flow with phase separation

, 2001
We study the impact of a localized defect in a cellular automaton model for traffic flow which exhibits metastable states and phase separation.
A. Pottmeier, A. Schadschneider, Barlovic, Barlovic, Chowdhury, Chowdhury, Csahok, Daganzo, Diedrich, Emmerich, Evans, Evans, Helbing, Helbing, Janowsky, Janowsky, Kerner, Kerner, Kerner, Kerner, Knospe, Knospe, Krug, Krug, Lee, Lee, Lee, M. Schreckenberg, Nagatani, Nagel, Neubert, Neubert, Popkov, R. Barlovic, W. Knospe, Yukawa   +35 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Mutation screening of the USH2A gene reveals two novel pathogenic variants in Chinese patients causing simplex usher syndrome 2

BMC Ophthalmology, 2020
Background Usher syndrome (USH) is the most prevalent cause of the human genetic deafness and blindness. USH type II (USH2) is the most common form of USH, and USH2A is the major pathogenic gene for USH2. For expanding the spectrum of USH2A mutations and
Chenhao He, Xinyu Liu, Zilin Zhong, Jianjun Chen   +3 more
doaj   +1 more source