Results 81 to 90 of about 1,902,450 (297)

Lattice packings with gap defects are not completely saturated [PDF]

open access: yes, 2003
We show that a honeycomb circle packing in $\R^2$ with a linear gap defect cannot be completely saturated, no matter how narrow the gap is. The result is motivated by an open problem of G. Fejes T\'oth, G. Kuperberg, and W.
Kuperberg, Greg   +2 more
core  

New Global Defect Structures

open access: yes, 2003
We investigate the presence of defects in systems described by real scalar field in (D,1) spacetime dimensions. We show that when the potential assumes specific form, there are models which support stable global defects for D arbitrary.
A. Sen   +10 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Statistics of defect motion in spatiotemporal chaos in inclined layer convection

open access: yes, 2002
We report experiments on defect-tracking in the state of undulation chaos observed in thermal convection of an inclined fluid layer. We characterize the ensemble of defect trajectories according to their velocities, relative positions, diffusion, and ...
Bodenschatz, Eberhard, Daniels, Karen E.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

open access: yesFEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Development and Validation of Novel Diagnostic Models for Biliary Atresia in a Large Cohort of Chinese PatientsResearch in Context

open access: yesEBioMedicine, 2018
Background & aims: The overlapping features of biliary atresia (BA) and the other forms of neonatal cholestasis (NC) with different causes (non-BA) has posed challenges for the diagnosis of BA.
Rui Dong   +7 more
doaj   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

Novel compound heterozygous pathogenic variants in ASCC1 in a Chinese patient with spinal muscular atrophy with congenital bone fractures 2 : Evidence supporting a "Definitive" gene‐disease relationship

open access: yesMolecular Genetics & Genomic Medicine, 2020
Background A very limited spectrum of ASCC1 pathogenic variants had been reported in six (mostly consanguineous) families with spinal muscular atrophy with congenital bone fractures 2 [OMIM #616867] since 2016. Methods A proband from a non‐consanguineous
Weiliang Lu   +15 more
doaj   +1 more source

Trajectories in a space with a spherically symmetric dislocation

open access: yes, 2012
We consider a new type of defect in the scope of linear elasticity theory, using geometrical methods. This defect is produced by a spherically symmetric dislocation, or ball dislocation.
Alcides F. Andrade   +11 more
core   +1 more source

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