Results 41 to 50 of about 1,092,582 (286)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Plant Flavonoids in Mediterranean Species: A Focus on Flavonols as Protective Metabolites under Climate Stress

Plants, 2022
Flavonoids are specialized metabolites largely widespread in plants where they play numerous roles including defense and signaling under stress conditions.
Justine Laoué, Catherine Fernandez, Elena Ormeño   +2 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1

Frontiers in Immunology
BackgroundIncreased levels of plasminogen activator inhibitor-1 (PAI-1) in tumors have been found to correlate with poor clinical outcomes in patients with cancer. Although abundant data support the involvement of PAI-1 in cancer progression, whether PAI-
Abd Aziz Ibrahim, Taku Fujimura, Tomoko Uno, Tomoya Terada, Ken-ichi Hirano, Hiroyuki Hosokawa, Akio Ohta, Toshio Miyata, Kiyoshi Ando, Takashi Yahata   +9 more
doaj   +1 more source

Defense Mechanism Of Amba Reflected In Laksmi Pamuntjak’s The Questions Of Red Novels (2014): A Psychoanalytic Approach [PDF]

, 2017
This research aims to analyze defense mechanism of Amba, reflected on Laksmi Pamuntjak’s The Questions of Red novel, the purpose of the research is reveal what is defense mechanism, what kind of defense mechanism and how is defense mechanism reflected in
, Dr. Abdillah Nugroho, M.Hum, Kahar, Fitrah Abdul   +1 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Quorum-Sensing-Induced Bacteriophage Defense Mechanism

mBio, 2013
One of the key determinants of the size, composition, structure, and development of a microbial community is the predation pressure by bacteriophages. Accordingly, bacteria have evolved a battery of antiphage defense strategies.
Nina Molin Høyland-Kroghsbo, Rasmus Baadsgaard Mærkedahl, Sine Lo Svenningsen   +2 more
doaj   +1 more source

Deciphering the Genome-Wide Transcriptomic Changes during Interactions of Resistant and Susceptible Genotypes of American Elm with Ophiostoma novo-ulmi

Journal of Fungi, 2022
Dutch elm disease (DED), caused by Ophiostoma novo-ulmi (Onu), is a destructive disease of American elm (Ulmus americana L.). The molecular mechanisms of resistance and susceptibility against DED in American elm are still largely uncharacterized.
Md Tabibul Islam, Jose Freixas Coutin, Mukund Shukla, Amandeep Kaur Dhaliwal, Martha Nigg, Louis Bernier, Sherif M. Sherif, Praveen K. Saxena   +7 more
doaj   +1 more source

Defense Mechanisms in E. a. Poe's Selected Short Stories the Black Cat & the Tell-Tale Heart [PDF]

, 2018
Defense mechanism is strategies the ego uses to defend itself against the anxiety provoked by conflicts. The aim of the research is to describe the types of defense mechanism in two of Poe's selected short stories, The Black Cat & The Tell-Tale Heart ...
Tenrisanna, R. (Rasynal)
core