Results 91 to 100 of about 1,111,681 (344)

Mechanisms of Antiphage Defense in Prokaryotes

Антибиотики и Химиотерапия
The globalization of the problem of the formation of bacterial strains poly- and pan-resistant to known antimicrobial drugs creates high risks in the healthcare sector.
А. D. Daudova, Yu. Z. Demina, R. O. Abdrakhmanova, G. R. Baeva, T. S. Rubalskaia, A. L. Yasenyavskaya, O. V. Rubalsky, M. A. Samotrueva   +7 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

Single‐Cell RNA Seq in Sydenham Chorea Shows B Cell HLA‐DR/DQ Upregulation and Plasma Cell Proteasomal Activation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The pathogenesis of Sydenham chorea remains unclear. We report a 10‐year‐old girl presenting with subacute chorea and mild carditis following Streptococcal throat infection. Single‐cell RNA sequencing on 30,794 peripheral immune cells from the patient and two sex‐matched controls revealed nine immune cell clusters.
Velda X. Han, Brooke A. Keating, Brian S. Gloss, Xianzhong Lau, Ruwani Dissanayake, Hiroya Nishida, Jessica Hayes, Shrujna Patel, Shekeeb S. Mohammad, Russell C. Dale   +9 more
wiley   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source

C-Terminal Domain of Hemocyanin, a Major Antimicrobial Protein from Litopenaeus vannamei: Structural Homology with Immunoglobulins and Molecular Diversity

Frontiers in Immunology, 2017
Invertebrates rely heavily on immune-like molecules with highly diversified variability so as to counteract infections. However, the mechanisms and the relationship between this variability and functionalities are not well understood.
Yue-Ling Zhang, Bo Peng, Hui Li, Fang Yan, Hong-Kai Wu, Xian-Liang Zhao, Xiang-Min Lin, Shao-Ying Min, Yuan-Yuan Gao, San-Ying Wang, Yuan-You Li, Xuan-Xian Peng   +11 more
doaj   +1 more source

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

The Role of Religious Orientation and Defense Mechanisms in the Use of Sexual Pornography [PDF]

روانشناسی بالینی و شخصیت
Introduction: The widespread negative effects of pornography, which is an increasingly prevalent issue in today's society, have raised numerous questions regarding the factors that influence the tendency to engage with it.
Zahra Pirbonyan, Zahra Nikmanesh, Sana Nourimoghadam   +2 more
doaj   +1 more source

An SDN-based Approach For Defending Against Reflective DDoS Attacks

, 2018
Distributed Reflective Denial of Service (DRDoS) attacks are an immanent threat to Internet services. The potential scale of such attacks became apparent in March 2018 when a memcached-based attack peaked at 1.7 Tbps.
Erb, Benjamin, Kargl, Frank, Kleber, Stephan, Lukaseder, Thomas, Stölzle, Kevin   +4 more
core   +1 more source

The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen, Ali Behram Salar, Abdulkadir Ermis, Erkingul Birday, Lutfu Hanoglu, Bayram Ufuk Sakul   +5 more
wiley   +1 more source

In silico characterization of a pathogenesis-related protein PR-1 from Theobroma grandiflorum : S01P11 [PDF]

, 2013
The cupuassu (Theobroma grandiflorum [Wild. Ex Sperg.] K. Schum) is a native species of Brazil with a large industrial potential related to the use of the fruit pulp and seeds.
Alves, Rafael Moyses, Marcellino, Lucilia Helena, Micheli, Fabienne, Silva, Edson M.A, Silva, R.J.S   +4 more
core