Results 211 to 220 of about 54,233 (258)
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International Journal of Biochemistry and Cell Biology, 1999
Human beta-defensin-2 (HBD-2) is a cysteine-rich cationic low molecular weight antimicrobial peptide recently discovered in psoriatic lesional skin. It is produced by a number of epithelial cells and exhibits potent antimicrobial activity against Gram-negative bacteria and Candida, but not Gram-positive Staphylococcus aureus. HBD-2 represents the first
Jürgen Harder, Jens-Michael Schröder
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Human beta-defensin-2 (HBD-2) is a cysteine-rich cationic low molecular weight antimicrobial peptide recently discovered in psoriatic lesional skin. It is produced by a number of epithelial cells and exhibits potent antimicrobial activity against Gram-negative bacteria and Candida, but not Gram-positive Staphylococcus aureus. HBD-2 represents the first
Jürgen Harder, Jens-Michael Schröder
exaly +3 more sources
Nature Reviews Microbiology, 2004
Defensins are endogenous, cysteine-rich antimicrobial peptides that contribute to host defence against bacterial, fungal and viral infections. There are three subfamilies of defensins in primates: alpha-defensins are most common in neutrophils and Paneth cells of the small intestine; beta-defensins protect the skin and the mucous membranes of the ...
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Defensins are endogenous, cysteine-rich antimicrobial peptides that contribute to host defence against bacterial, fungal and viral infections. There are three subfamilies of defensins in primates: alpha-defensins are most common in neutrophils and Paneth cells of the small intestine; beta-defensins protect the skin and the mucous membranes of the ...
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2013
The term defensin relates to a set of host defense peptides (HDPs)in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel bet-sheetcore, with an alpha-helical stretch also present in some membrers, Defensins of different origins exhibit structural and functional similarities, with
ANTCHEVA, Nikolinka +2 more
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The term defensin relates to a set of host defense peptides (HDPs)in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel bet-sheetcore, with an alpha-helical stretch also present in some membrers, Defensins of different origins exhibit structural and functional similarities, with
ANTCHEVA, Nikolinka +2 more
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Molecular Immunology, 2003
Acne a disease of the pilosebaceous unit is characterised by hypercornification and hyperkeratosis of outer root sheath (ORS) and sebaceous duct and perilesional infiltrate. Lesions may be characterised as "non"-inflammatory versus inflammatory. Hypercornification of the distal ORS and the pilosebaceous duct in concert with increased sebum production ...
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Acne a disease of the pilosebaceous unit is characterised by hypercornification and hyperkeratosis of outer root sheath (ORS) and sebaceous duct and perilesional infiltrate. Lesions may be characterised as "non"-inflammatory versus inflammatory. Hypercornification of the distal ORS and the pilosebaceous duct in concert with increased sebum production ...
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Science, 2002
The innate immune system responses rapidly to pathogens, either by obstruction and direct killing of microbes or by activation of the adaptive arm of the immune system. Defensins have feet in both camps, and two studies add insight into how they work (see the Perspective by Ganz).
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The innate immune system responses rapidly to pathogens, either by obstruction and direct killing of microbes or by activation of the adaptive arm of the immune system. Defensins have feet in both camps, and two studies add insight into how they work (see the Perspective by Ganz).
+4 more sources
Multispecific myeloid defensins
Current Opinion in Hematology, 2007This review describes recent progress in our understanding of defensins and their contributions to innate immunity. Defensins are small, cysteine-rich endogenous antibiotic peptides. Human neutrophils contain large amounts of three alpha-defensins (HNP-1-HNP-3), and smaller amounts of a fourth, HNP-4. Monocytes and macrophages generally lack defensins,
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Disulfide Bridges in Defensins
Current Topics in Medicinal Chemistry, 2015Defensins are small cationic cysteine rich peptides, which usually contain 18-45 amino acids and possess amphiphilic properties. The term "defensin" was coined as the sequences of rabbit and human leukin/phagocytin molecules were first reported in 1985.
Bing-Chuan, Zhao +4 more
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Current Opinion in Hematology, 2014
Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
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Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
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Defensins of vertebrate animals
Current Opinion in Immunology, 2002During the past year, novel beta-defensins of mice and men have been identified, together with a novel defensin subfamily (the circular or 'theta' minidefensins) in primates. Insight into the evolution of defensins has been obtained from structural studies, and several mechanisms related to microbial resistance to defensins have been delineated.
Robert I, Lehrer, Tomas, Ganz
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Cell and Tissue Research, 2010
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
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The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
openaire +2 more sources