Results 211 to 220 of about 42,582 (271)
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Journal of Bone and Joint Surgery. American volume, 2018
Background: Diagnosing periprosthetic joint infection after total joint arthroplasty is often challenging. The alpha defensin test has been recently reported as a promising diagnostic test for periprosthetic joint infection. The goal of this study was to
William Z. Stone +6 more
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Background: Diagnosing periprosthetic joint infection after total joint arthroplasty is often challenging. The alpha defensin test has been recently reported as a promising diagnostic test for periprosthetic joint infection. The goal of this study was to
William Z. Stone +6 more
semanticscholar +1 more source
Molecular Immunology, 2003
Acne a disease of the pilosebaceous unit is characterised by hypercornification and hyperkeratosis of outer root sheath (ORS) and sebaceous duct and perilesional infiltrate. Lesions may be characterised as "non"-inflammatory versus inflammatory. Hypercornification of the distal ORS and the pilosebaceous duct in concert with increased sebum production ...
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Acne a disease of the pilosebaceous unit is characterised by hypercornification and hyperkeratosis of outer root sheath (ORS) and sebaceous duct and perilesional infiltrate. Lesions may be characterised as "non"-inflammatory versus inflammatory. Hypercornification of the distal ORS and the pilosebaceous duct in concert with increased sebum production ...
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Defensins and inflammation: The role of defensins in inflammatory bowel disease
Journal of Gastroenterology and Hepatology, 2009AbstractDefensins are antimicrobial peptides produced at a variety of epithelial surfaces. In the intestinal tract, they contribute to host immunity and assist in maintaining the balance between protection from pathogens and tolerance to normal flora. However, attenuated expression of defensins compromises host immunity and hence may alter the balance ...
Malith, Ramasundara +3 more
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Disulfide Bridges in Defensins
Current Topics in Medicinal Chemistry, 2015Defensins are small cationic cysteine rich peptides, which usually contain 18-45 amino acids and possess amphiphilic properties. The term "defensin" was coined as the sequences of rabbit and human leukin/phagocytin molecules were first reported in 1985.
Bing-Chuan, Zhao +4 more
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Cell and Tissue Research, 2010
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
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The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
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2013
The term defensin relates to a set of host defense peptides (HDPs)in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel bet-sheetcore, with an alpha-helical stretch also present in some membrers, Defensins of different origins exhibit structural and functional similarities, with
ANTCHEVA, Nikolinka +2 more
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The term defensin relates to a set of host defense peptides (HDPs)in vertebrates, invertebrates, plants, and molds that display structural similarities based on a cystine stabilized antiparallel bet-sheetcore, with an alpha-helical stretch also present in some membrers, Defensins of different origins exhibit structural and functional similarities, with
ANTCHEVA, Nikolinka +2 more
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Current Opinion in Hematology, 2014
Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
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Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
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Defensins of vertebrate animals
Current Opinion in Immunology, 2002During the past year, novel beta-defensins of mice and men have been identified, together with a novel defensin subfamily (the circular or 'theta' minidefensins) in primates. Insight into the evolution of defensins has been obtained from structural studies, and several mechanisms related to microbial resistance to defensins have been delineated.
Robert I, Lehrer, Tomas, Ganz
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Functional synergism of Human Defensin 5 and Human Defensin 6
Biochemical and Biophysical Research Communications, 2015The gut epithelium is critically involved in maintaining intestinal immune homeostasis. Acting as a physical barrier, it separates the intestinal microflora from cells of the immune system. In addition to its barrier function, the intestinal epithelium expresses defensins, natural, endogenous antimicrobial peptides.
Aiping, Zhao, Wuyuan, Lu, Erik, de Leeuw
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Techniques for Plant Defensin Production
Current Protein & Peptide Science, 2010To defend themselves from attack by pathogens, plants can rely only on their innate defense systems. Defensins are antimicrobial peptides that contribute to plant immunity by displaying a direct cidal activity against various pathogens, some of which are responsible for plant diseases. These determine a significant decrease in the quality and safety of
PADOVAN, LARA +3 more
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