Results 61 to 70 of about 54,404 (260)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Artificial β-defensin based on a minimal defensin template

Biochemical Journal, 2009
We have designed and chemically synthesized an artificial β-defensin based on a minimal template derived from the comparative analysis of over 80 naturally occurring sequences. This molecule has the disulfide-bridged β-sheet core structure of natural β-defensins and shows a robust salt-sensitive antimicrobial activity against bacteria and yeast, as ...
ANTCHEVA, Nikolinka, MORGERA F, CREATTI L, VACCARI, LISA, PAG U, PACOR, SABRINA, SHAI Y, SAHL H. G, TOSSI, ALESSANDRO   +8 more
openaire   +4 more sources

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Redox Active Antimicrobial Peptides in Controlling Growth of Microorganisms at Body Barriers

Antioxidants, 2021
Epithelia in the skin, gut and other environmentally exposed organs display a variety of mechanisms to control microbial communities and limit potential pathogenic microbial invasion.
Piotr Brzoza, Urszula Godlewska, Arkadiusz Borek, Agnieszka Morytko, Aneta Zegar, Patrycja Kwiecinska, Brian A. Zabel, Artur Osyczka, Mateusz Kwitniewski, Joanna Cichy   +9 more
doaj   +1 more source

A gene signature for post-infectious chronic fatigue syndrome [PDF]

, 2009
Background: At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential expression of mRNA from a large number of genes.
Abhijit Chaudhuri, AK Smith, B Cameron, B Evengård, Celia Cannon, D Buchwald, D Maglott, DR Shafren, G Broderick, G Kennedy, G Kennedy, H Fang, H Gräns, IB Jeffery, J Gu, J Smith, J Vecchiet, John W Gow, JR Kerr, JR Kerr, JW Gow, JW Gow, K Fukuda, KA Kurian, L Carmel, L Jason, LA Karaivanova, LJ Morrison, LM Cope, M Maes, M Maes, M Steinau, N Kaushik, Pawel Herzyk, Peter O Behan, PJ McLaren, R Breitling, R Breitling, R Edgar, RA Irizarry, RB Moss, RS Richards, RW Finberg, S Hafenstein, S Mikami, S Wessely, S Wessely, SD Vernon, SD Vernon, Suzanne Hagan, T Pham, T Saiki, T Watanabe, T Whistler, Y Manuel   +54 more
core   +4 more sources

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Essential Oil of Foeniculum vulgare Mill. as a Green Fungicide and Defense-Inducing Agent against Fusarium Root Rot Disease in Vicia faba L.

Biology, 2021
Fusarium solani, the causative agent of root rot disease is one of the major constraints of faba bean (Vicia faba L.) yield worldwide. Essential oils have become excellent plant growth stimulators besides their antifungal properties.
Mona M. Khaleil, Maryam M. Alnoman, Elsayed S. Abd Elrazik, Hayat Zagloul, Ahmed Mohamed Aly Khalil   +4 more
doaj   +1 more source

Human beta defensin 2 selectively inhibits HIV-1 in highly permissive CCR6+CD4+ T cells [PDF]

, 2017
Chemokine receptor type 6 (CCR6)+CD4+ T cells are preferentially infected and depleted during HIV disease progression, but are preserved in non-progressors.
Aaron Christensen-Quick, Alfredo Garzino-Demo, Chang, Daher, Liao, Lingling Sun, Mark Lafferty, Wuyuan Lu   +7 more
core   +1 more source

Mouse neutrophils lack defensins [PDF]

Infection and Immunity, 1992
Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.
P B, Eisenhauer, R I, Lehrer
openaire   +2 more sources