Results 201 to 210 of about 28,067 (241)
Some of the next articles are maybe not open access.
Molecular Immunology, 2003
Acne a disease of the pilosebaceous unit is characterised by hypercornification and hyperkeratosis of outer root sheath (ORS) and sebaceous duct and perilesional infiltrate. Lesions may be characterised as "non"-inflammatory versus inflammatory. Hypercornification of the distal ORS and the pilosebaceous duct in concert with increased sebum production ...
openaire +2 more sources
Acne a disease of the pilosebaceous unit is characterised by hypercornification and hyperkeratosis of outer root sheath (ORS) and sebaceous duct and perilesional infiltrate. Lesions may be characterised as "non"-inflammatory versus inflammatory. Hypercornification of the distal ORS and the pilosebaceous duct in concert with increased sebum production ...
openaire +2 more sources
Defensins and inflammation: The role of defensins in inflammatory bowel disease
Journal of Gastroenterology and Hepatology, 2009AbstractDefensins are antimicrobial peptides produced at a variety of epithelial surfaces. In the intestinal tract, they contribute to host immunity and assist in maintaining the balance between protection from pathogens and tolerance to normal flora. However, attenuated expression of defensins compromises host immunity and hence may alter the balance ...
Malith, Ramasundara +3 more
openaire +2 more sources
Cellular and Molecular Life Sciences CMLS, 2006
The last decade led to the discovery and characterization of several human beta-defensins. Analysis of genomic information indicates that the number of beta-defensin-like molecules encoded by the human genome may number in the tens. Growing interest in beta-defensins steadily enhances our knowledge about various aspects of their gene location ...
M, Pazgier +4 more
openaire +2 more sources
The last decade led to the discovery and characterization of several human beta-defensins. Analysis of genomic information indicates that the number of beta-defensin-like molecules encoded by the human genome may number in the tens. Growing interest in beta-defensins steadily enhances our knowledge about various aspects of their gene location ...
M, Pazgier +4 more
openaire +2 more sources
Current Opinion in Hematology, 2014
Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
openaire +2 more sources
Defensins are a major family of antimicrobial peptides expressed predominantly in neutrophils and epithelial cells, and play important roles in innate immune defense against infectious pathogens. Their biological functions in and beyond innate immunity, structure and activity relationships, mechanisms of action, and therapeutic potential continue to be
Le, Zhao, Wuyuan, Lu
openaire +2 more sources
Disulfide Bridges in Defensins
Current Topics in Medicinal Chemistry, 2015Defensins are small cationic cysteine rich peptides, which usually contain 18-45 amino acids and possess amphiphilic properties. The term "defensin" was coined as the sequences of rabbit and human leukin/phagocytin molecules were first reported in 1985.
Bing-Chuan, Zhao +4 more
openaire +2 more sources
Cell and Tissue Research, 2010
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
openaire +2 more sources
The innate immune system is the first line of defense against many common microorganisms, which can initiate adaptive immune responses to provide increased protection against subsequent re-infection by the same pathogen. As a major family of antimicrobial peptides, defensins are widely expressed in a variety of epithelial cells and sometimes in ...
Linda, Hazlett, Minhao, Wu
openaire +2 more sources
Functional synergism of Human Defensin 5 and Human Defensin 6
Biochemical and Biophysical Research Communications, 2015The gut epithelium is critically involved in maintaining intestinal immune homeostasis. Acting as a physical barrier, it separates the intestinal microflora from cells of the immune system. In addition to its barrier function, the intestinal epithelium expresses defensins, natural, endogenous antimicrobial peptides.
Aiping, Zhao, Wuyuan, Lu, Erik, de Leeuw
openaire +2 more sources
Techniques for Plant Defensin Production
Current Protein & Peptide Science, 2010To defend themselves from attack by pathogens, plants can rely only on their innate defense systems. Defensins are antimicrobial peptides that contribute to plant immunity by displaying a direct cidal activity against various pathogens, some of which are responsible for plant diseases. These determine a significant decrease in the quality and safety of
PADOVAN, LARA +3 more
openaire +4 more sources
Science, 1999
Defensins are antimicrobial peptides produced by cells as part of the host9s immune defense system against invading pathogens. A Perspective by Tomas Ganz highlights three papers that provide new insights into the structure and function of vertebrate defensins. In mice, a-defensins produced by the Paneth cells of the small intestine help defend
openaire +2 more sources
Defensins are antimicrobial peptides produced by cells as part of the host9s immune defense system against invading pathogens. A Perspective by Tomas Ganz highlights three papers that provide new insights into the structure and function of vertebrate defensins. In mice, a-defensins produced by the Paneth cells of the small intestine help defend
openaire +2 more sources
Multispecific myeloid defensins
Current Opinion in Hematology, 2007This review describes recent progress in our understanding of defensins and their contributions to innate immunity. Defensins are small, cysteine-rich endogenous antibiotic peptides. Human neutrophils contain large amounts of three alpha-defensins (HNP-1-HNP-3), and smaller amounts of a fourth, HNP-4. Monocytes and macrophages generally lack defensins,
openaire +2 more sources