Results 41 to 50 of about 6,178 (191)

Perbedaan Kadar Thyroid Stimulating Hormone dan Free Thyroxine pada Pasien Talasemia Β-Mayor dengan Kelasi Besi Deferasirox dan Deferiprone

Sari Pediatri, 2018
Latar belakang. Talasemia β Mayor merupakan kelainan herediter yang disebabkan gangguan produksi rantai globin. Transfusi rutin menyebabkan kelebihan besi yang tertimbun dalam jaringan sehingga menyebabkan kardiomiopati, gangguan liver, dan komplikasi ...
Aries - Krisbiyantoro, Harsono Salimo, Annang Giri Moelyo   +2 more
doaj   +1 more source

Two-year long safety and efficacy of deferasirox film-coated tablets in patients with thalassemia or lower/intermediate risk MDS: phase 3 results from a subset of patients previously treated with deferasirox in the ECLIPSE study

Experimental Hematology & Oncology, 2020
Background Despite the proven benefits of iron chelation therapy (ICT) in the management of chronic iron overload and related complications, compliance to long-term ICT is challenging.
Immacolata Tartaglione, Raffaella Origa, Antonis Kattamis, Michael Pfeilstöcker, Sibel Gunes, Susanne Crowe, Niamh Fagan, Beatrice Vincenzi, Giovan Battista Ruffo   +8 more
doaj   +1 more source

Simultaneous Determination of Plasma Deferasirox and Deferasirox-Iron Complex Using an HPLC-UV System and Pharmacokinetics of Deferasirox in Patients With beta-Thalassemia Major: Once-daily Versus Twice-daily Administration

, 2017
Purpose: Deferasirox (DEFR), when administered BID, improves iron overload and decreases DEFR-related adverse effects in patients with beta-thalassemia major.
Lu, Meng-Yao;Wang, Ning;Wu, Wen-Hsin;Lai, Cheng-Wei;Kuo, Pei-Hsin;Chiang, Po-Hung;Lin, Kai-Hsin;Wu, Tzu-Hua, 盧孟佑;林凱信   +1 more
core   +1 more source

Deferasirox Targeting Ferroptosis Synergistically Ameliorates Myocardial Ischemia Reperfusion Injury in Conjunction With Cyclosporine A

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Ferroptosis, an iron‐dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition‐driven necrosis, which is inhibited by cyclosporine A ...
Kosei Ishimaru, Masataka Ikeda, Hiroko Deguchi Miyamoto, Shun Furusawa, Ko Abe, Masatsugu Watanabe, Takuya Kanamura, Satoshi Fujita, Ryohei Nishimura, Takayuki Toyohara, Shouji Matsushima, Tomoko Koumura, Ken‐ichi Yamada, Hirotaka Imai, Hiroyuki Tsutsui, Tomomi Ide   +15 more
doaj   +1 more source

Advances in iron chelation therapy: transitioning to a new oral formulation

Drugs in Context, 2017
Iron overload is a concern for patients who require repeated red-blood-cell transfusions due to conditions such as sickle cell disease, thalassemia, or myelodysplastic syndromes.
Nirmish R Shah
doaj   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid dimethylformamide monosolvate

Acta Crystallographica Section E, 2012
In the molecule of deferasirox dimethylformamide solvate, C21H15N3O4·C3H7NO, the central 1,2,4-triazole ring is tilted with respect to the benzoic acid and one of the 2-hydroxyphenyl units but coplanar with the other 2-hydroxyphenyl group, as ...
H. S. Yathirajan, Saji Thomas, A. S. Dayananda, Suchada Chantrapromma, Hoong-Kun Fun   +4 more
doaj   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox

, 2015
Background and AimDevelopment of effective antifibrotic treatments that can be translated to clinical practice is an important challenge in contemporary hepatology. A recent report on -thalassemia patients demonstrated that deferasirox treatment reversed
Bridle, Kim R., de Guzman, C. Erika, Jaskowski, Lesley, Subramaniam, V. Nathan, Jaskowski, L., Campbell, Catherine M., Crawford, D.H.G., Crawford, Darrell H. G., de Guzman, C.E., Santrampurwala, N., Campbell, C.M., Sobbe, Amy, Santrampurwala, Nishreen, Sobbe, A., Bridle, K.R., Clouston, Andrew D., Clouston, A.D., Subramaniam, V.N.   +17 more
core   +1 more source

Protective Effects of Vitamin C Concomitant Treatment on Deferasirox-induced Renal Toxicity in Rats

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2020
Background and Aim: Deferasirox (Exjade) is an iron-chelating drug used in patients with beta-thalassemia major. Oxidative stress is among f the major causes of nephrotoxicity and its progression.
Taha Fereydouni, Saeed Hajihashemi, Parsa Yousefichaijan, Ali Rahbari   +3 more
doaj