Results 51 to 60 of about 5,411 (177)

Parkinson's Disease: The Epidemiology, Risk Factors, Molecular Pathogenesis, Prevention, and Therapy

MedComm, Volume 6, Issue 12, December 2025.
This graphical abstract summarizes the major components of this review on Parkinson's disease, including epidemiological trends, risk factor classification, peripheral and molecular pathogenesis, and both preventive and therapeutic strategies. The framework reflects the multidimensional organization of the text, covering disease burden, mechanistic ...
Xue‐Yao Guo, Dong‐Yan Song, Ming‐Yang Wu, Jing‐Qi Zhang, Jia‐Yi Li, Lin Yuan   +5 more
wiley   +1 more source

A Patient with Beta-Propeller Protein-Associated Neurodegeneration: Treatment with Iron Chelation Therapy [PDF]

Journal of Movement Disorders, 2018
We present a case of beta-propeller protein-associated neurodegeneration, a form of neurodegeneration with brain iron accumulation. The patient harbored a novel mutation in the WDR45 gene.
Shen-Yang Lim, Ai Huey Tan, Azlina Ahmad-Annuar, Susanne A. Schneider, Ping Chong Bee, Jia Lun Lim, Norlisah Ramli, Mohamad Imran Idris   +7 more
doaj   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, Volume 3, Issue 4, December 2025.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Pharmacogenomic and Clinical Predictors of Deferasirox Response in Transfusion‐Dependent Thalassemia Identified Using Whole‐Genome Sequencing

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Deferasirox is a widely used oral iron chelator in patients with transfusion‐dependent thalassemia, but considerable variability in treatment response remains a clinical challenge. This study applied whole‐genome sequencing to investigate genetic predictors of deferasirox response in 88 Thai patients.
Kittika Yampayon, Watchara Sakares, Krittin Pitinanon, Chanin Limwongse, Somdet Srichairatanakool, Pimpisid Koonyosying, Chonlaphat Sukasem, Kwankom Triparn, Jittima Piriyapongsa, Supachai Ekwattanakit, Vip Viprakasit, Varalee Yodsurang   +11 more
wiley   +1 more source

Solubility data of deferiprone in propylene glycol and 1-propanol mixtures at 293.2–323.2 K

Chemical Thermodynamics and Thermal Analysis
Experimental determination on solubility of deferiprone in propylene glycol + 1-propanol mixtures and their saturated solution's densities were reported at atmospheric pressure (101 kPa) from 293.2 to 313.2 K.
Homa Rezaei, Elaheh Rahimpour, Abolghasem Jouyban   +2 more
doaj   +1 more source

Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against Vibrio anguillarum Infection in Fish [PDF]

, 2021
Miguel Balado, Diego Rey-Varela, Ana M. Albela, Manuel L. Lemos   +3 more
openalex   +1 more source

Quantitative Iron Measurements in the Basal Ganglia of NBIA Patients Using QSM: Insights From a Tertiary Center

Annals of Clinical and Translational Neurology, Volume 12, Issue 11, Page 2305-2316, November 2025.
ABSTRACT Objective Neurodegeneration with brain iron accumulation (NBIA) comprises rare genetic disorders characterized by predominantly extrapyramidal symptoms and iron deposition in the basal ganglia. Conventional magnetic resonance imaging (MRI) detects qualitative changes but cannot accurately quantify iron accumulation. Quantitative susceptibility
Özge Uygun, Alpay Özcan, Fuat Kaan Aras, Evrim Bozdemir, Sibel Uğur İşeri, Koray Kırımtay, Arzu Karabay, Murat Gültekin, Nihan Hande Akçakaya, Orkhan Mammadov, Gülay Kır, Dilek İnce Günal, Neşe Tuncer, Fatma Betül Özdilek, Banu Özen Barut, Ercan Köse, Hülya Apaydın, Asuman Ali, Sultan Çağırıcı, Pınar Topaloğlu, Alp Dinçer, Zuhal Yapıcı   +21 more
wiley   +1 more source

Untangling Tau and Iron: Exploring the Interaction Between Iron and Tau in Neurodegeneration

Frontiers in Molecular Neuroscience, 2018
There is an emerging link between the accumulation of iron in the brain and abnormal tau pathology in a number of neurodegenerative disorders, such as Alzheimer’s disease (AD).
Shalini S. Rao, Paul Anthony Adlard
doaj   +1 more source

Comparison of Efficacy, Safety, and Humanistic Outcomes of Iron-Chelation Therapy in Pediatrics Suffering from Transfusion-Dependent β-Thalassemia Major

Indian Journal of Medical Specialities, 2020
Introduction: Beta-thalassemia major (β-TM) is a severe form of genetic disorder that affects the patient's quality of life. Iron-chelation therapy (ICT) is recommended in these patients to reduce the complications (iron overload) associated with ...
Narayana Goruntla, P. Stephen Azarya, Mahitha Chalagundla, Dasaratha Ramaiah Jinka, Pradeepkumar Bhupalam, Vishnuvandana Bandaru   +5 more
doaj   +1 more source