Results 131 to 140 of about 13,449 (262)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source

hERG1 channels and potential therapeutics for long QT syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider, Kelly A. Aromolaran, Michael C. Sanguinetti, Ademuyiwa S. Aromolaran   +3 more
wiley   +1 more source

Adaptive Pudendal Nerve Stimulation: A Pilot Study on Safety, Technical Feasibility, and Clinical Effect

Neurourology and Urodynamics, Volume 45, Issue 7, Page 1258-1265, September 2026.
ABSTRACT Purpose To evaluate the safety, procedural feasibility, and pilot clinical outcomes for a new implanted device delivering adaptive pudendal nerve stimulation. Materials and Methods Thirteen adult women with treatment‐refractory mixed (n = 8) or urge (n = 5) urinary incontinence were implanted with a Picostim‐DyNeuMo system incorporating an ...
Siemen Herroelen, Charles H. Knowles, Sean Doherty, Mo Benjaber, Jacob Kerr, Karen Wendt, Aidan Crawley, Tim Denison, Stefan De Wachter   +8 more
wiley   +1 more source

Dynamic Risk Assessment for the Development of Persistent Atrial Fibrillation Using Statistical and Machine Learning Approaches

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
Machine learning using 6‐month rolling AF burden from cardiac implantable devices accurately predicts 1‐year progression to persistent atrial fibrillation. Higher AF intensity and frequency strongly identify high‐risk patients, enabling dynamic, point‐in‐time risk stratification to support earlier, targeted clinical intervention.
Alexei Nakonechnyi, Shaul Geliaks, Ilan Goldenberg, Dillon J. Dzikowicz, Emre Aktas, Susan Schleede, Scott McNitt, Agam Purohit, Burr W. Hall, Spencer Z. Rosero, David Z. Huang, Amole O. Ojo, Wojciech Zareba, Michael Christof, Mehmet K. Aktas   +14 more
wiley   +1 more source

Optimization of novel compounds using computer‐aided drug design for treatment of cardiac arrhythmia

British Journal of Pharmacology, Volume 183, Issue 17, Page 5407-5420, September 2026.
Background and Purpose Loss‐of‐function mutations of the voltage‐gated Kv7.1 (KCNQ/KCNE1) channels lead to cardiac arrhythmia such as long QT syndrome, characterized by a prolonged QT interval . One strategy to correct the prolonged QT interval is to design molecules that activate KCNQ1/KCNE1 channels and restore the QT interval.
Jessica Jowais, Laura M. Castro‐Gonzalez, Alessia Golluscio, D. Peter Tieleman, H. Peter Larsson   +4 more
wiley   +1 more source

Systematic review of physical and dosimetric criteria for managing CIEDs in radiotherapy: A medical physicist's perspective

Journal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Aim Current radiotherapy (RT) guidelines for Cardiac Implantable Electronic Devices (CIEDs) are largely based on clinical management strategies and retrospective reports. This systematic review adopts a medical physics perspective to provide a critical, quantitative analysis of the technical evidence required for developing robust safety ...
Tiziana Malatesta, Agnese Barbareschi, Rita Alaimo, Emilio Mezzenga, Maria Grazia Brambilla, Anna Delana, Stefano Andreoli, Rita Consorti, Stefano Ren Kaiser, Marco Mapelli, Eugenia Moretti, Maria Mormile, Giulia Rambaldi Guidasci, Mara Severgnini, Lidia Strigari, Maria Daniela Falco   +15 more
wiley   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, Volume 36, Issue 67, 20 August 2026.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Advancements in Enzymatic Biofuel Cells for Wearable Electrochemical Biosensors: Powering Point‐of‐Care Health Monitoring

Advanced Sensor Research, Volume 5, Issue 8, August 2026.
Advances in enzymatic biofuel cells are highlighted through innovative electrode architectures, enzyme immobilization strategies, and hybrid integration with triboelectric, piezoelectric, and thermoelectric energy harvesters. These emerging approaches improve power output, operational stability, and biocompatibility, advancing self‐powered wearable and
Rashid Khan, Mohammad Abrar Uddin, Yi Jae Lee, Taeil Kim   +3 more
wiley   +1 more source

Expanding the Phenotype of TUFM ‐Related Combined Oxidative Phosphorylation Deficiency 4

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1884-1889, August 2026.
ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier, Jodi Warman‐Chardon, Danielle K. Bourque   +2 more
wiley   +1 more source