Results 121 to 130 of about 760,723 (266)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Az öröklött és szerzett kataláz hiány klinikai és klinikai biokémiai vonatkozásai = Clinical and biochemical consequences of inherited and acquired forms of catalase deficiency

, 2007
A hidrogénperoxid az élőszervezetekre gyakorolt oxidatív, toxikus hatásáról volt ismert, míg szerepe az újabb irodalmi adatok alapján átértékelődött.
Góth, László, Tarnai, Ildikó, Sükei, Eszter, Imre, Sándor   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aromatase Deficiency

, 2013
Aromatase deficiency disrupts the synthesis of estradiol, resulting in hirsutism of mothers during gestation of an affected child; pseudohermaphroditism and virilization in women; and tall stature, osteoporosis and obesity in ...
ROCHIRA, Vincenzo, CARANI, Cesare
core  

Vitamin D Deficiency: Universal Risk Factor for Multifactorial Diseases?

, 2011
In the Western world, the majority of morbidity and mortality are caused by multifactorial diseases. Some risk factors are related to more than one type of disease.
Wolffenbuttel, Bruce H. R.; id_orcid, Rudolf A. de Boer, Wolffenbuttel, Bruce H. R., Stolk, Ronald P.; id_orcid, de Boer, Rudolf A., Slaets, Joris P. J., Ronald P. Stolk, Gerjan Navis, Navis, Gerjan, Stolk, Ronald P., Joris P.J. Slaets, Bruce H.R. Wolffenbuttel, Martin H. de Borst, de Borst, Martin H., de Borst, Martin H.; id_orcid   +14 more
core   +1 more source

Vitamin B12 (cobalamin) deficiency in gastroenterological diseases - review

Introduction: Vitamin B12 is a water-soluble vitamin found primarily in animal-derived products such as red meat, dairy, and eggs. An essential substance for its absorption is the intrinsic factor, produced by the parietal cells of the stomach.
Rabenda, Michal, Janik, Piotr, Zatyka, Piotr, Opala, Dominika, Słomczyński, Adam, Osuch, Dobromiła, Pawłowska, Agata   +6 more
core   +2 more sources

The Effect of miR-129-5p on the Proliferation and Osteogenic Differentiation of Human Dental Pulp Stem Cells

International Dental Journal
Objective: To investigate the role of microRNA-129-5p (miR-129-5p) in the proliferation and osteogenic differentiation of human dental pulp stem cells (hDPSCs).
Fan Yang, Zonghao Zhang, Xufang Qiu, Hongbing Lv   +3 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Iron deficiency in the United States [PDF]

"Iron deficiency is the most common known form of nutritional deficiency. Its prevalence is highest among young children and women of childbearing age (particularly pregnant women).

core  

Changes of methylation at enhancers appear to be essential for HIV infection progression

Clinical Epigenetics
Background We studied the influence of the European HIV-1 subtype B (most common in the Western and Central Europe) and subtype A6 (prevalent in Eastern Europe including Ukraine and Russia) on host methylome during infection progression and in virus ...
Olga Taryma-Leśniak, Jan Bińkowski, Kaja Mielczak, Bogusz Aksak-Wąs, Malwina Karasińska-Cieślak, Marta Sobalska-Kwapis, Dominik Strapagiel, Miłosz Parczewski, Tomasz Kazimierz Wojdacz   +8 more
doaj   +1 more source