Results 121 to 130 of about 1,194,112 (311)

Control of HIV across the WHO European region: progress and remaining challenges

The Lancet Regional Health. Europe
Summary: Despite the ambitious global goal to control HIV transmissions by 2030, more than 30% of people with HIV from the WHO European Region show persistent transmissible levels of the virus.
Miłosz Parczewski, Deniz Gökengin, Ann Sullivan, Julia de Amo, Gus Cairns, Stela Bivol, Giorgi Kuchukhidze, Marta Vasylyev, Jürgen K. Rockstroh   +8 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Mechanisms of endothelial injury and transplant-associated thrombotic microangiopathy in tandem autologous hematopoietic stem cell transplant for neuroblastoma

Haematologica, 2023
Anthony Sabulski, Sheyar Abdullah, Nathan Luebbering, Benjamin Aunins, Caitlin Castillo, Kelly Lake, Alexandra Duell, Lauren Strecker, Lucille Langenberg, William Broomhead, Scott DiMeo, Elizabeth A. Odegard, Jason T. Blackard, Assem G. Ziady, Alix E. Seif, Christopher E. Dandoy, Benjamin L. Laskin, Sonata Jodele, Stella M. Davies   +18 more
doaj   +1 more source

Zebrafish study provides evidence for Porphyromonas gingivalis outer membrane vesicles eliciting Alzheimer’s disease-like pathologies

Frontiers in Cellular and Infection Microbiology
IntroductionPeriodontitis has been epidemiologically linked to an increased risk of Alzheimer’s disease (AD), yet the mechanistic contribution of periodontal pathogens remains insufficiently understood.
Jianbin Guo, Kaijin Lin, Kaijin Lin, Ruiyun Liang, Ruiyun Liang, Lingxia Jiang, Xiaozhen He, Jiawei Chen, Jiawei Chen, Minqian Zheng, Minqian Zheng   +10 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Deletion of dltD gene modulates biofilm matrix and acid metabolism to attenuate Streptococcus mutans cariogenicity

Frontiers in Cellular and Infection Microbiology
IntroductionStreptococcus mutans (SM) is one of the key pathogenic bacteria in the occurrence and development of dental caries. Its complex virulence regulation network has become an important target in current ecological caries prevention research. This
Jingyun Du, Jingyun Du, Jingyun Du, Shan Huang, Shan Huang, Yijun Li, Yijun Li, Zhoucheng Qiu, Zhoucheng Qiu, Yujia Hao, Yujia Hao, Jing Huang, Jing Huang, Ling Zhan, Shuai Chen, Shuai Chen, Xiaojing Huang, Xiaojing Huang   +17 more
doaj   +1 more source

Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia? [PDF]

, 2013
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM.
Alfonsi, Simona, Bullon, Pedro, Carrión, Ángel Manuel, Cordero, Mario D., Díaz-Parrado, Eduardo, Sánchez Alcázar, José Antonio   +5 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Piezo-Photo-Fenton Catalyst For Oral Antibacterial And Wastewater Treatment

International Dental Journal
Aim or purpose: This study aims to develop a synergistic piezoelectric-photo-Fenton catalytic system based on iron-based ferromagnetic materials, enabling the fabrication of multifunctional antibacterial piezoelectric nanomaterials.
Lu Hui Li, Shuai Chen, Xiu Qing Wang, Shu Jun Zhang   +3 more
doaj   +1 more source