Results 101 to 110 of about 760,723 (266)
, 2015 Disturbed magnesium (Mg2+) homoeostasis and increased levels of OS (oxidative stress) are associated with poor clinical outcomes in patients suffering from neurodegenerative, cardiovascular and metabolic diseases.
Aikaterini Anagnostopoulou +6 more
core +1 more source
EFFECT OF CERTAIN PIGMENTS ON PERFORIVIANCE AND IMMUNE RESPONSE OF CHICKS AS A MODEL [PDF]
Assiut Veterinary Medical Journal, 2000 H.M. Abd El-Hafeez +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Iron Deficiency Anemia and School Participation [PDF]
Iron-deficiency anemia is among the worldç—´ most widespread health problems, especially for children, but it is rarely studied by economists. This paper evaluates the impact of a health intervention delivering iron supplementation and deworming drugs to
Gustavo J. Bobonis
core
Clinical Trial Design for Alpha-1 Antitrypsin Deficiency: A Model for Rare Diseases
, 2015 Clinical research in rare diseases, including alpha-1 antitrypsin deficiency (AATD), faces challenges not shared by common disease research. These challenges may include the limited number of patient volunteers available for research, lack of natural ...
Edelman, Jonathan M +15 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Immunologie Deficiency Diseases in Man
, 1970 J. A. Immunologie Deficiency Diseases in Man. In: Population, 25ᵉ année, n°3, 1970.
J., A.
core
The burden of iodine deficiency
Introduction Iodine deficiency is a global issue; however, no comparable assessments of the burden of iodine deficiency have been conducted worldwide. Hence, we measured the estimated annual percentage changes (EAPCs) from 1990 to 2019.
Zhifei Wu, Yu Liu, Wenjuan Wang
core +1 more source
[Vitamin D deficiency and cardiovascular diseases]
, 2015 Vitamin D deficiency is a condition that affects a high percentage of individuals of all ages. Considerable attention has been paid recently to the possible role of deficiency of this vitamin in the development of several chronic diseases, including ...
Ciccone, Marco Matteo +7 more
core +1 more source