Results 91 to 100 of about 760,723 (266)

Mutations in SRD5B1 (AKR1D1), the gene encoding Delta(4)-3-oxosteroid 5 beta-reductase, in hepatitis and liver failure in infancy [PDF]

, 2003
Background: A substantial group of patients with cholestatic liver disease in infancy excrete, as the major urinary bile acids, the glycine and taurine conjugates of 7alpha-hydroxy-3-oxo-4-cholenoic acid and 7alpha, 12alpha-dihydroxy-3- oxo-4-cholenoic ...
Duran, M., Scambler, PJ, Custard, E. J., Bouquet, J, Lemonde, H. A., Clayton, P. T., Duran, M, Overmars, H, Bouquet, J., Scambler, P.J., Lemonde, H., Clayton, P.T., Custard, EJ, Scambler, P. J., Clayton, PT, Lemonde, HA, Custard, E.J., Overmars, H.   +17 more
core   +1 more source

Salvianolic acid B functionalized injectable GelMA hydrogel for pulpitis in a vital pulp therapy: a dual anti-inflammatory property and enhanced reparative dentinogenesis activity material

BMC Oral Health
Background Vital pulp therapy (VPT) is recognized as a minimally invasive alternative to root canal treatment for teeth with initial and mild to moderate pulpitis.
Zongli Li, Dongdong Xu, Xiaojing Huang
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Iron supplementation and malaria: a randomised, placebo-controlled field trial on women and children in rural Ethiopia. [PDF]

The health situation in Sub-Saharan Africa is complex and multifactorial. Along with its poorly developed economy and lack of basic health services, vector-borne diseases and nutritional disorders are major contributors to the high morbidity and ...
Adam, Zenaw
core   +1 more source

Mature Incisor With Internal Resorption: Laser-Assisted Regenerative Endodontic Procedures

International Dental Journal
Introduction: Internal root resorption (IRR), characterized by progressive dentin destruction, may cause root perforations, fracture, and even tooth loss. Regenerative endodontic procedures (REPs), which can promote root development, lack strong evidence
Ruonan Chen, Guoying Lu, Xiuqing Wang
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

CURRENT STATUS OF IODINE-DEFICIENCY DISEASES

, 2010
The article focuses on the issue of iodine-deficiency pathology. It provides historical background on this issue and reviews the progress made abroad in preventing iodine deficiency.
V.M. Krasnov
core  

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency. [PDF]

, 1996
Autosomal recessive mutations in the 17 beta-hydroxysteroid dehydrogenase 3 gene impair the formation of testosterone in the fetal testis and give rise to genetic males with female external genitalia.
Blethen, Sandra L., Geissler, Wayne M., Mendonca, Berenice B., Schwarz, Hans P., Russell, David D., Bloise, Walter, Grumbach, Melvin M., Davis, Daphne L., Andersson, Stefan, New, Maria I., Wu, Ling, Witchel, Selma F., Griffin, James E., Cutler Jr., Gordon B., Wilson, Jean D.   +14 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source