Results 221 to 230 of about 1,194,112 (311)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Decalogue of Best Practices in Alpha-1 Antitrypsin Deficiency. [PDF]

Open Respir Arch
Hernández-Pérez JM, Dasí F, Miravitlles M, Diab-Cáceres L, Casas-Maldonado F, Martínez-Delgado B, Esquinas-López C, Moya-Álvarez V, Calle M, Michel-de La Rosa FJ, Callejas-González FJ, Rodríguez-García C, Barrecheguren M, Parra-Parra I, Torres-Durán M, Curi-Chércoles S, Lázaro-Asegurado L, Bustamante A, Castillo-Corullón S, López-Campos JL.   +19 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

IL12RB1 Deficiency Appearing in North America: Expanding the Clinical Phenotypes. [PDF]

Clin Infect Dis
Wang C, Marciano BE, Harris AJ, Johnston AM, Apaydin Arikan E, Bayer DK, Solomon BD, Price NB, Platt CD, Modi AJ, Shaker MS, Seroogy CM, Johnson D, Kleiner DE, Chirombo Kluczynski L, Anderson VL, Daub JR, Berghout J, Oler AJ, Walkiewicz MA, Similuk M, Lewis DB, Galgiani JN, Freeman AF, Rosen LB, Hsu AP, Zerbe CS, Holland SM.   +27 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Exploring the role of C1-inhibitor in thrombotic diseases. [PDF]

Blood Adv
Hansen JB.
europepmc   +1 more source

Immunodeficiency Diseases and Tumor Immunobiology [PDF]

, 1974
Abramoff, Peter A., Duquesnoy, Rene J.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Research hotspots and trends in insulin resistance and hypothyroidism: A bibliometric analysis. [PDF]

Medicine (Baltimore)
Yao L, Zhang L, Jiang R, Chen S, Zhong C, Fang J, Tan Y, Liu M.   +7 more
europepmc   +1 more source