Results 71 to 80 of about 45,478 (297)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Uniqueness of solutions to a system of differential inclusions

Electronic Journal of Differential Equations, 2000
In this paper we study the uniqueness of solutions to the initial and Dirichlet boundary-value problem of differential inclusions $$ Delta u_i+ablacdotvec {B_i} (u_1,u_2,dots,u_N)in {partial F_i(u_i) over partial t}, quad i=1,2,dots,N, $$ where $vec{B_i}(
Chunpeng Wang, Jingxue Yin
doaj  

Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

eLife
Nociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel NaV1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical ...
Yu-Feng Xie, Jane Yang, Stéphanie Ratté, Steven A Prescott   +3 more
doaj   +1 more source

Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

eLife, 2014
Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability.
Stéphanie Ratté, Yi Zhu, Kwan Yeop Lee, Steven A Prescott   +3 more
doaj   +1 more source

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

A Note on Contraction Degeneracy

, 2004
The parameter contraction degeneracy --- the maximum minimum degree over all minors of a graph --- is a treewidth lower bound and was first defined in [3]. In experiments it was shown that this lower bound improves upon other treewidth lower bounds [3].
Thomas Wolle, Hans L. Bodlaender, Arie M. C. A. Koster, Bodlaender, H.L., Koster, A.M.C.A., Wolle, T.   +5 more
core   +1 more source

A Tale of Two Entangled Instabilities—The Dual Role of δ-O in HgBa2Can-1CunO2(n+1)+δ

Entropy, 2015
Low-energy instabilities in the hole-doped cuprates include, besides short range antiferromagnetic fluctuations and superconductivity, also ubiquitous translational and rotational symmetry breakings.
Itai Panas
doaj   +1 more source

The declination degeneracy in interferometric astrometry

, 2012
Context. Interferometric astrometry at radio and optical wavelengths serves as a fundamental and high-precision method for measuring the positions of celestial objects and for geodetic and Earth orientation measurements. Aims. We determine the
D. Buscher
core   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

Heritability of types of a pregeometry relative to a family of relational structures

Қарағанды университетінің хабаршысы. Математика сериясы
A series of geometrical and topological properties induced by structures, including degeneration, modularity, local modularity, projectivity, local finiteness, etc., play an important role in clarifying structural relationships and in classifying basic ...
S.B. Malyshev, S.V. Sudoplatov
doaj   +1 more source