Results 1 to 10 of about 45,946 (274)
Towards a Dynamic Clamp for Neurochemical Modalities [PDF]
Sensors, 2015 The classic dynamic clamp technique uses a real-time electrical interface between living cells and neural simulations in order to investigate hypotheses about neural function and structure.
Catalina Maria Rivera +8 more
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Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing [PDF]
Frontiers in Physiology, 2018 Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in ...
Francis A. Ortega +4 more
doaj +7 more sources
Single electrode dynamic clamp with StdpC [PDF]
Journal of Neuroscience Methods, 2012 Dynamic clamp is a powerful approach for electrophysiological investigations allowing researchers to introduce artificial electrical components into target neurons to simulate ionic conductances, chemical or electrotonic inputs or connections to other cells.
Vincenzo Marra +2 more
exaly +5 more sources
Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp [PDF]
Frontiers in Pharmacology, 2021 Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes.
Arie O. Verkerk +8 more
doaj +5 more sources
Generalization of the dynamic clamp concept in neurophysiology and behavior. [PDF]
PLoS ONE, 2012 The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons.
Pablo Chamorro +5 more
doaj +9 more sources
StdpC: A modern dynamic clamp [PDF]
Journal of Neuroscience Methods, 2006 With the advancement of computer technology many novel uses of dynamic clamp have become possible. We have added new features to our dynamic clamp software StdpC ("Spike timing-dependent plasticity Clamp") allowing such new applications while conserving the ease of use and installation of the popular earlier Dynclamp 2/4 package. Here, we introduce the
Thomas Nowotny +2 more
exaly +5 more sources
Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp [PDF]
Frontiers in Pharmacology, 2022 The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death.
Chunyun Du +9 more
doaj +2 more sources
Causes of Transient Instabilities in the Dynamic Clamp [PDF]
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2009 The dynamic clamp is a widely used method for integrating mathematical models with electrophysiological experiments. This method involves measuring the membrane voltage of a cell, using it to solve computational models of ion channel dynamics in real-time, and injecting the calculated current(s) back into the cell. Limitations of this technique include
Robert J Butera
exaly +3 more sources
eLife, 2022 Reciprocal inhibition is a building block in many sensory and motor circuits. We studied the features that underly robustness in reciprocally inhibitory two neuron circuits.
Ekaterina Morozova +2 more
doaj +1 more source
Circulation: Arrhythmia and Electrophysiology, 2015 Mutations in KCNH2 (hERG) underlie the long-QT2 syndrome. Most long-QT2 mutations produce a trafficking defect resulting in a decrease in n, the number of functional channels on the cell surface. Some mutations can also alter gating characteristics.
Thomas Nowotny, Pablo Varona
openaire +3 more sources