Results 21 to 30 of about 45,946 (274)

Dynamic compression bone clamp for transverse fractures

Plastic Surgery, 2000
A bone clamp with the following important features is described: it provides a dynamic compression force to transversely fractured bone ends before they are fixed with internal hardware; it is designed to reduce transverse bone fractures; and it holds the bone with sharp, opposing points like a towel clip.
Donald H Lalonde
openaire   +2 more sources

Implementing dynamic clamp with synaptic and artificial conductances in mouse retinal ganglion cells [PDF]

J Vis Exp, 2013
Ganglion cells are the output neurons of the retina and their activity reflects the integration of multiple synaptic inputs arising from specific neural circuits.
Huang, Jinyu, Stiefel, Klaus M. (R17042), Protti, Dario A.   +2 more
core   +2 more sources

Antilipolytic Insulin Sensitivity Indices Measured during an Oral Glucose Challenge: Associations with Insulin-Glucose Clamp and Central Adiposity in Women without Diabetes [PDF]

Endocrinology and Metabolism
Background Tissue overexposure to non-esterified fatty acids (NEFA) contributes to the development of metabolic conditions, with insulin-mediated suppression of lipolysis being an important mechanism in limiting this overexposure.
Foued Naimi, Christophe Richer dit Laflèche, Marie-Claude Battista, André C. Carpentier, Jean-Patrice Baillargeon   +4 more
doaj   +3 more sources

Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer

Structural Dynamics, 2015
Several X-ray crystal structures of the E. coli core clamp loader containing the five core (δ′, δ, and three truncated γ) subunits have been determined, but they lack the ψ and χ subunits.
Farzaneh Tondnevis, Richard E. Gillilan, Linda B. Bloom, Robert McKenna   +3 more
doaj   +2 more sources

Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

eLife, 2020
Across biological systems, cooperativity between proteins enables fast actions, supra-linear responses, and long-lasting molecular switches. In the nervous system, however, the function of cooperative interactions between voltage-dependent ionic channels
Paul Pfeiffer, Alexei V Egorov, Franziska Lorenz, Jan-Hendrik Schleimer, Andreas Draguhn, Susanne Schreiber   +5 more
doaj   +1 more source

Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

eLife, 2020
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in new ...
Marco A Navarro, Autoosa Salari, Jenna L Lin, Luke M Cowan, Nicholas J Penington, Mirela Milescu, Lorin S Milescu   +6 more
doaj   +1 more source

Transient outward K+ current (ITO) reduction prolongs action potentials and promotes afterdepolarisations: a dynamic-clamp study in human and rabbit cardiac atrial myocytes [PDF]

, 2012
Background and aim: Human atrial transient outward K+ current (ITO) is decreased in a variety of cardiac pathologies, but how ITO reduction alters action potentials (AP) and arrhythmia mechanisms is poorly understood, owing to non-selectivity of ITO ...
Marshall, G.E., Dempster, J., Smith, G.L., Rankin, A.C., Workman, A.J.   +4 more
core   +1 more source

Classical and numerical approaches to determining V-section band clamp axial stiffness [PDF]

, 2014
V-band clamp joints are used in a wide range of applications to connect circular flanges, for ducts, pipes and the turbocharger housing. Previous studies and research on V-bands are either purely empirical or analytical with limited applicability on the ...
Khodabakhshi, Goodarz, Barrans, Simon, Muller, Matthias, Khodabakhshi Goodarz, Barrans, Simon M., Muller Matthias, Barrans Simon M.   +6 more
core   +1 more source

Loading Dynamics of a Sliding DNA Clamp [PDF]

Angewandte Chemie, 2014
AbstractSliding DNA clamps are loaded at a ss/dsDNA junction by a clamp loader that depends on ATP binding for clamp opening. Sequential ATP hydrolysis results in closure of the clamp so that it completely encircles and diffuses on dsDNA. We followed events during loading of an E. coli β clamp in real time by using single‐molecule FRET (smFRET).
Cho, Won-Ki, Jergic, Slobodan, Kim, Daehyung, Dixon, Nicholas, Lee, Jong-Bong   +4 more
openaire   +5 more sources

Rapid genetic algorithm optimization of a mouse computational model: Benefits for anthropomorphization of neonatal mouse cardiomyocytes

Frontiers in Physiology, 2012
While the mouse presents an invaluable experimental model organism in biology, its usefulness in cardiac arrhythmia research is limited in some aspects due to major electrophysiological differences between murine and human action potentials (APs).
Corina Teodora Bot, Armen R. Kherlopian, Armen R. Kherlopian, Francis A. Ortega, David J. Christini, David J. Christini, Trine eKrogh-Madsen, Trine eKrogh-Madsen, Trine eKrogh-Madsen   +8 more
doaj   +1 more source