Results 41 to 50 of about 11,801 (293)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

On the Non-Newtonian Fluid Equation with a Source Term and a Damping Term

Journal of Function Spaces, 2018
A kind of non-Newtonian fluid equation with a damping term and a source term is considered. After giving a result of the existence, if the diffusion coefficient is degenerate on the boundary, the local stability of the weak solutions is established ...
Huashui Zhan, Yongping Li
doaj   +1 more source

Initial-boundary value problem for the time-fractional degenerate diffusion equation

Вестник КазНУ. Серия математика, механика, информатика, 2022
In this paper the initial-boundary value problems for the one-dimensional linear time-fractional diffusion equations with the time-fractional derivative ∂ α t of order α ∈ (0, 1) in the variable t and time-degenerate diffusive coefficients t β with β ≥ 1
A. G. Smadiyeva
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Bistable equation with discontinuous density dependent diffusion with degenerations and singularities

Electronic Journal of Qualitative Theory of Differential Equations, 2021
In this article we introduce rather general notion of the stationary solution of the bistable equation which allows to treat discontinuous density dependent diffusion term with singularities and degenerations, as well as degenerate or non-Lipschitz ...
Pavel Drábek, Michaela Zahradnikova
doaj   +1 more source

Gradient estimates for degenerate diffusion equations. I

Mathematische Annalen, 1982
SynopsisWe establish upper and lower bounds for various norms of solutions and their gradients for the equation ut = div (|∇u|m−1 ∇u) in ℝN in terms of the norms of the initial data. Based on the L∞ estimate of ∇u, we conclude that u(x, t) is Lipschitz continuous in space-time, for all t>0, whenever u(x,0) is in L1(ℝN).
Alikakos, Nicholas D., Rostamian, Ruben
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Singular elliptic equations with directional diffusion

Mathematics in Engineering, 2021
We investigate conditions for the existence and uniqueness of viscosity solutions of the Dirichlet problem for a degenerate elliptic equation describing a stationary diffusion, which may take place in a partial number of spatial directions, with a ...
Antonio Vitolo
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Stability of Densities for Perturbed Degenerate Diffusions [PDF]

Theory of Probability & Its Applications, 2017
We study the sensitivity of the densities of some Kolmogorov like degenerate diffusion processes with respect to a perturbation of the coefficients of the non-degenerate component. Under suitable (quite sharp) assumptions we quantify how the pertubation of the SDE affects the density.
openaire   +3 more sources