Results 91 to 100 of about 625,920 (299)

Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan, Elizabeth I. Pierpont, Amena S. Fine, Reena V. Kartha   +3 more
wiley   +1 more source

Type 2 Diabetes Mellitus Is Associated With Faster Degeneration of Bioprosthetic Valve [PDF]

, 2011
Roberto Lorusso, Sandro Gelsomino, Fabiana Lucà, Giuseppe De Cicco, Giuseppe Billè, Rocco Carella, Emmanuel Villa, Giovanni Troise, Mario Viganò, Carlo Banfı, Carmine Gazzaruso, P. Gagliardotto, Lorenzo Menicanti, Francesco Formica, Giovanni Paolini, Stefano Benussi, Ottavio Alfieri, Matteo Rocco Pastore, Sandro Ferrarese, Giovanni Mariscalco, G. Di Credico, Cristian Leva, Claudio Russo, Aldo Cannata, Roberto Trevisan, Ugolino Livi, Roberto Scrofani, Carlo Antona, Andrea Sala, Gian Franco Gensini, Jos G. Maessen, Andrea Giustina   +31 more
openalex   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration

Molecular Neurodegeneration
Background Cortical atrophy is a common manifestation in behavioral variant frontotemporal degeneration (bvFTD), exhibiting spatial heterogeneity across various genetic subgroups, which may be driven by distinct biological mechanisms. Methods We employed
Ting Shen, Jacob W. Vogel, Vivianna M. Van Deerlin, EunRan Suh, Laynie Dratch, Jeffrey S. Phillips, Lauren Massimo, Edward B. Lee, David J. Irwin, Corey T. McMillan   +9 more
doaj   +1 more source

Comprehensive Analysis of the Candidate GenesCCL2,CCR2, andTLR4in Age-Related Macular Degeneration [PDF]

, 2008
Dominiek D. G. Despriet, Arthur A. Bergen, Joanna E. Merriam, Jana Zernant, Gaetano R. Barile, R. Theodore Smith, Irene Barbazetto, S. van Soest, Arne Bakker, Paulus T.V.M. de Jong, Rando Allikmets, Caroline C. W. Klaver   +11 more
openalex   +1 more source

Adult lifespan maturation and degeneration patterns in gray and white matter: A mean apparent propagator (MAP) MRI study

, 2022
Mustapha Bouhrara, Alexandru Avram, Matthew Kiely, Aparna Trivedi, Dan Benjamini   +4 more
openalex   +1 more source

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s disease and frontotemporal lobar degeneration [PDF]

, 2020
Anna Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Pałasz, Charles R. Harrington, Franz Theuring, Claude M. Wischik, Gernot Riedel, Grażyna Niewiadomska   +9 more
openalex   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source

Association of Systemic Inflammatory Factors with Progression to Advanced Age-related Macular Degeneration

, 2021
Brandie D. Wagner, Jennifer L. Patnaik, Alan G. Palestine, Ashley Frazer‐Abel, Rebecca Baldermann, V. Michael Holers, Talisa E. de Carlo, Naresh Mandava, Anne M. Lynch   +8 more
openalex   +2 more sources

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source