Results 21 to 30 of about 559,157 (325)

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

The spatial form periosteal-bone complex promotes bone regeneration by coordinating macrophage polarization and osteogenic-angiogenic events

Materials Today Bio, 2021
Bone defects associated with soft tissue injuries are an important cause of deformity that threatens people’s health and quality of life. Although bone substitutes have been extensively explored, effective biomaterials that can coordinate early ...
C. Zhao, P. Qiu, M. Li, K. Liang, Z. Tang, P. Chen, J. Zhang, S. Fan, X. Lin   +8 more
doaj   +1 more source

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs [PDF]

, 2002
It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous
Beltran, E, De Decker, S, Gomes, S A, Kenny, P J, Packer, R M A, Volk, H A   +5 more
core   +4 more sources

LncRNA AC006064.4–201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1

Biomarker Research, 2023
Background Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA development.
Panyang Shen, Jun Gao, Shaohan Huang, Chenan You, Haitao Wang, Pengyu Chen, Teng Yao, Tianyou Gao, Bohao Zhou, Shuying Shen, Xing Zhao, Jianjun Ma   +11 more
doaj   +1 more source

mTORC1 induces plasma membrane depolarization and promotes preosteoblast senescence by regulating the sodium channel Scn1a

Bone Research, 2022
Senescence impairs preosteoblast expansion and differentiation into functional osteoblasts, blunts their responses to bone formation-stimulating factors and stimulates their secretion of osteoclast-activating factors.
Ajuan Chen, Jian Jin, Shasha Cheng, Zezheng Liu, Cheng Yang, Qingjing Chen, Wenquan Liang, Kai Li, Dawei Kang, Zhicong Ouyang, Chenfeng Yao, Xiaochun Bai, Qingchu Li, Dadi Jin, Bin Huang   +14 more
doaj   +1 more source

Aneurysmal Degeneration of Medically-Managed Acute Type B Aortic Dissections† [PDF]

Journal of Vascular Surgery, 2014
hypertension (89.9% vs 90.4%, P 1⁄4 .61). OPs were associated with higher mortality rates (1.9% vs 0.6%, P 1⁄4 .0004), postoperative worsening of renal function (1.4% vs 0.4%, P 1⁄4 .002), cardiac events (3.5% vs 1.4%, P < .0001), respiratory complications (3.2% vs 1.1%, P < .0001), and combined outcomes (6.8% vs 2.3%, P < .0001).
Durham, Christopher A., Aranson, Nathan J., Ergul, Emel A., Wang, Linda J., Patel, Virendra I., Cambria, Richard P., Conrad, Mark F.   +6 more
openaire   +1 more source

Post-treatment follow-up study of abdominal cystic echinococcosis in Tibetan communities of northwest Sichuan Province, China [PDF]

, 2011
Background: Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, with the liver as the most frequently affected organ, is known to be highly endemic in Tibetan communities of northwest Sichuan Province. Antiparasitic
A Ito, A McVie, AG Saimot, Akira Ito, C Franchi, DL Morris, Dongchuan Qiu, DP McManus, E Brunetti, E Brunetti, E Larrieu, E Ortona, GR Leggatt, H Cohen, H Wen, Hector H. Garcia, I Gadea, J Eckert, J Horton, k Vutova, L Opatrny, LA Gil-Grande, M Stojkovic, M Verastegui, MW Lightowlers, N Ben Nouir, Ning Xiao, O Doiz, P Kern, P Moro, P Venkatesan, Philip S. Craig, R Rigano, Renqing Pengcuo, RJ Horton, RJ Horton, S Ioppolo, SD Lawn, T Junghanss, T Li, T Li, T Romig, T Todorov, Tiaoying Li, W Mamuti, W Zhang, Xingwang Chen, Y Sbihi, Yasuhito Sako, ZS Pawlowski   +49 more
core   +3 more sources

Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration [PDF]

, 2017
10.1194/jlr.M073684Journal of Lipid Research5891785 ...
Apte, Rajendra S., Chee, Miao Ling, Cheng, Ching-Yu, Fan, Qiao, Gan, Alfred, Gemmy Cheung, Chui Ming, Khor, Chiea Chuen, Mathur, Ranjana, Tai, E. Shyong, Wong, Tien Yin, Yeo, Ian   +10 more
core   +2 more sources

Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs

Frontiers in Pharmacology, 2022
Irreversible sensorineural hearing loss is one of the most common side effects after cisplatin treatment. Prevention and reversal of hearing loss caused by cisplatin are of great importance for cancer patients, especially children. Oxidative stress is an
Dafei Li, Dafei Li, Haiyan Zhao, Haiyan Zhao, Piao Xu, Piao Xu, Qiongping Lin, Qiongping Lin, Tingting Zhao, Tingting Zhao, Chubing Li, Chubing Li, Zhong-Kai Cui, Zhong-Kai Cui, Guangyong Tian, Guangyong Tian   +15 more
doaj   +1 more source

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Nature Communications, 2021
Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows that after TBI, injured neurons, mainly those in the hippocampus, release osteogenic ...
Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong-Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai   +17 more
doaj   +1 more source