Results 21 to 30 of about 546,188 (282)

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Nature Communications, 2021
Clinical evidence has established that concomitant traumatic brain injury (TBI) accelerates bone healing, but the underlying mechanism is unclear. This study shows that after TBI, injured neurons, mainly those in the hippocampus, release osteogenic ...
Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong-Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai   +17 more
doaj   +1 more source

Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs

Frontiers in Pharmacology, 2022
Irreversible sensorineural hearing loss is one of the most common side effects after cisplatin treatment. Prevention and reversal of hearing loss caused by cisplatin are of great importance for cancer patients, especially children. Oxidative stress is an
Dafei Li, Dafei Li, Haiyan Zhao, Haiyan Zhao, Piao Xu, Piao Xu, Qiongping Lin, Qiongping Lin, Tingting Zhao, Tingting Zhao, Chubing Li, Chubing Li, Zhong-Kai Cui, Zhong-Kai Cui, Guangyong Tian, Guangyong Tian   +15 more
doaj   +1 more source

The Role of Nrf2 in Hearing Loss

Frontiers in Pharmacology, 2021
Hearing loss is a major unresolved problem in the world, which has brought a heavy burden to society, economy, and families. Hair cell damage and loss mediated by oxidative stress are considered to be important causes of hearing loss.
Dafei Li, Dafei Li, Haiyan Zhao, Haiyan Zhao, Zhong-Kai Cui, Zhong-Kai Cui, Guangyong Tian, Guangyong Tian   +7 more
doaj   +1 more source

Comparisons of the Efficacy and Safety of Total Knee Arthroplasty by Different Surgical Approaches: A Systematic Review and Network Meta‐analysis

Orthopaedic Surgery, 2022
The purpose of this network meta‐analysis was to investigate the efficacy and safety of total knee arthroplasty (TKA) considering seven different surgical approaches.
Jin‐long Zhao, Ling‐feng Zeng, Jian‐ke Pan, Gui‐hong Liang, He‐tao Huang, Wei‐yi Yang, Ming‐hui Luo, Jun Liu   +7 more
doaj   +1 more source

Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
Recently, various studies have identified circular RNAs (circRNAs) to play a significant role in tumorigenesis, thereby showing potential as novel tumor biomarkers.
Yining Xu, Yining Xu, Teng Yao, Haonan Ni, Rujie Zheng, Kangmao Huang, Yizhen Huang, Jun Gao, Di Qiao, Di Qiao, Shuying Shen, Jianjun Ma, Jianjun Ma   +12 more
doaj   +1 more source

Post-treatment follow-up study of abdominal cystic echinococcosis in Tibetan communities of northwest Sichuan Province, China [PDF]

, 2011
Background: Human cystic echinococcosis (CE), caused by the larval stage of Echinococcus granulosus, with the liver as the most frequently affected organ, is known to be highly endemic in Tibetan communities of northwest Sichuan Province. Antiparasitic
A Ito, A McVie, AG Saimot, Akira Ito, C Franchi, DL Morris, Dongchuan Qiu, DP McManus, E Brunetti, E Brunetti, E Larrieu, E Ortona, GR Leggatt, H Cohen, H Wen, Hector H. Garcia, I Gadea, J Eckert, J Horton, k Vutova, L Opatrny, LA Gil-Grande, M Stojkovic, M Verastegui, MW Lightowlers, N Ben Nouir, Ning Xiao, O Doiz, P Kern, P Moro, P Venkatesan, Philip S. Craig, R Rigano, Renqing Pengcuo, RJ Horton, RJ Horton, S Ioppolo, SD Lawn, T Junghanss, T Li, T Li, T Romig, T Todorov, Tiaoying Li, W Mamuti, W Zhang, Xingwang Chen, Y Sbihi, Yasuhito Sako, ZS Pawlowski   +49 more
core   +3 more sources

AMPK Signaling in Energy Control, Cartilage Biology, and Osteoarthritis

Frontiers in Cell and Developmental Biology, 2021
The adenosine monophosphate (AMP)–activated protein kinase (AMPK) was initially identified as an enzyme acting as an “energy sensor” in maintaining energy homeostasis via serine/threonine phosphorylation when low cellular adenosine triphosphate (ATP ...
Dan Yi, Dan Yi, Huan Yu, Huan Yu, Ke Lu, Ke Lu, Changshun Ruan, Changhai Ding, Changhai Ding, Liping Tong, Xiaoli Zhao, Di Chen, Di Chen   +12 more
doaj   +1 more source

Longitudinal grey and white matter changes in frontotemporal dementia and Alzheimer's disease [PDF]

, 2014
Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential ...
AF Fotenos, AT Du, B Dubois, BC Dickerson, Belinda Yew, Bonnie Y. K. Lam, C Bocti, C Davatzikos, C O'Callaghan, CE Krueger, CM Pleizier, D Chan, D Neary, DS Knopman, DS Yi, E Mioshi, E Mioshi, E Ratnavalli, Emma Flanagan, F Agosta, Francisco J. Esteban, G McKhann, H Hampel, Hans-Jürgen Huppertz, HJ Huppertz, HJ Rosen, J Ashburner, JC Looi, JL Whitwell, John R. Hodges, K Rascovsky, K Rascovsky, L Frings, Lars Frings, M Boccardi, M Broe, M Hornberger, M Hornberger, M Hornberger, MA Dalton, Michael Hornberger, Michael Hüll, O Piguet, P Lillo, PJ Nestor, RJ Perry, RR Davies, SM Resnick, TW Chow, WW Seeley, Y Benjamini   +50 more
core   +5 more sources

Morphometric analyses of the visual pathways in macular degeneration

, 2014
Introduction. Macular degeneration (MD) causes central visual field loss. When field defects occur in both eyes and overlap, parts of the visual pathways are no longer stimulated.
Baseler, Heidi A., Cornelissen, Frans W., Gouws, Andre, Greenlee, Mark W., Hernowo, Aditya T., Hooymans, Johanna M. M., Morland, Antony B., Plank, Tina, Prins, Doety   +8 more
core   +2 more sources

Widening use of dexamethasone implant for the treatment of macular edema [PDF]

, 2017
Sustained-release intravitreal 0.7 mg dexamethasone (DEX) implant is approved in Europe for the treatment of macular edema related to diabetic retinopathy, branch retinal vein occlusion, central retinal vein occlusion, and non-infectious uveitis.
Avitabile T., Bonfiglio V., Fallico M., Fichera S., Longo A., Macchi I., Pizzo A., Rapisarda C., Reibaldi M., Russo A.   +9 more
core   +2 more sources