Results 41 to 50 of about 4,732,020 (409)

The Immune Privilege of the Intervertebral Disc: Implications for Intervertebral Disc Degeneration Treatment

International Journal of Medical Sciences, 2020
The intervertebral disc (IVD) is the largest avascular organ of the body. It is composed of three parts: the nucleus pulposus (NP), the annulus fibrosus (AF) and the cartilaginous endplate (CEP).
Zhen Sun, Bing Liu, Zhuojing Luo
semanticscholar   +1 more source

Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs

Frontiers in Pharmacology, 2022
Irreversible sensorineural hearing loss is one of the most common side effects after cisplatin treatment. Prevention and reversal of hearing loss caused by cisplatin are of great importance for cancer patients, especially children. Oxidative stress is an
Dafei Li, Dafei Li, Haiyan Zhao, Haiyan Zhao, Piao Xu, Piao Xu, Qiongping Lin, Qiongping Lin, Tingting Zhao, Tingting Zhao, Chubing Li, Chubing Li, Zhong-Kai Cui, Zhong-Kai Cui, Guangyong Tian, Guangyong Tian   +15 more
doaj   +1 more source

Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football [PDF]

, 2017
IMPORTANCE: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE).
Abdolmohammadi, Bobak, Alosco, Michael L., Alvarez, Victor E., Baugh, Christine M., Cantu, Robert C., Chaisson, Christine E., Cormier, Kerry A., Daneshvar, Daniel H., Goldstein, Lee E., Huber, Bertrand R., Katz, Douglas I., Kiernan, Patrick T., Kowall, Neil W., Kubilus, Caroline A., Martin, Brett M., McClean, Michael D., McHale, Lisa, McKee, Ann C., Mez, Jesse, Montenigro, Phillip H., Murphy, Lauren, Nowinski, Christopher J., Solomon, Todd M., Stein, Thor D., Stern, Robert A., Tripodis, Yorghos, Weuve, Jennifer   +26 more
core   +1 more source

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Nature Communications, 2021
Concomitant traumatic brain injury accelerates bone healing, but the mechanism is unclear. Here, the authors show that injured neurons, mainly those in the hippocampus, release osteogenic miRNA-enriched small extracellular vesicles, which targete ...
Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong-Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai   +17 more
doaj   +1 more source

Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
Recently, various studies have identified circular RNAs (circRNAs) to play a significant role in tumorigenesis, thereby showing potential as novel tumor biomarkers.
Yining Xu, Yining Xu, Teng Yao, Haonan Ni, Rujie Zheng, Kangmao Huang, Yizhen Huang, Jun Gao, Di Qiao, Di Qiao, Shuying Shen, Jianjun Ma, Jianjun Ma   +12 more
doaj   +1 more source

Analysis of Pathogenic Variants Correctable With CRISPR Base Editing Among Patients With Recessive Inherited Retinal Degeneration.

JAMA ophthalmology, 2021
Importance Many common inherited retinal diseases are not easily treated with gene therapy. Gene editing with base editors may allow the targeted repair of single-nucleotide transition variants in DNA and RNA.
L. Fry, M. McClements, R. MacLaren
semanticscholar   +1 more source

Local well-posedness of a coupled Westervelt-Pennes model of nonlinear ultrasonic heating [PDF]

, 2021
High-Intensity Focused Ultrasound (HIFU) waves are known to induce localized heat to a targeted area during medical treatments. In turn, the rise in temperature influences their speed of propagation. This coupling affects the position of the focal region as well as the achieved pressure and temperature values.
arxiv   +1 more source

The potential role and trend of HIF-1α in intervertebral disc degeneration: Friend or foe?

Molecular Medicine Reports, 2021
Lower back pain (LBP) is one of the most common reasons for seeking medical advice in orthopedic clinics. Increasingly, research has shown that symptomatic intervertebral disc degeneration (IDD) is mostly related to LBP.
Yongjin Li, Shen Liu, Dayu Pan, Baoshan Xu, Xuewu Xing, Hengxing Zhou, Bin Zhang, Suzhe Zhou, G. Ning, S. Feng   +9 more
semanticscholar   +1 more source

Medical genetics: advances in brief: Canavan disease: from spongy degeneration to molecular analysis [PDF]

Journal of Medical Genetics, 1996
J. Clayton-Smith
openalex   +4 more sources

Predicting risk of late age-related macular degeneration using deep learning [PDF]

npj Digital Medicine, 2020
By 2040, age-related macular degeneration (AMD) will affect ~288 million people worldwide. Identifying individuals at high risk of progression to late AMD, the sight-threatening stage, is critical for clinical actions, including medical interventions and
Yifan Peng, T. Keenan, Qingyu Chen, Elvira Agr'on, Alexis Allot, W. Wong, E. Chew, Zhiyong Lu   +7 more
semanticscholar   +1 more source