Results 51 to 60 of about 559,157 (325)

Transcriptomic analyses and machine-learning methods reveal dysregulated key genes and potential pathogenesis in human osteoarthritic cartilage

Bone & Joint Research
Aims: This study aimed to explore the biological and clinical importance of dysregulated key genes in osteoarthritis (OA) patients at the cartilage level to find potential biomarkers and targets for diagnosing and treating OA. Methods: Six sets of gene
Di Zhao, Ling-feng Zeng, Gui-hong Liang, Ming-hui Luo, Jian-ke Pan, Yao-xing Dou, Fang-zheng Lin, He-tao Huang, Wei-yi Yang, Jun Liu   +9 more
doaj   +1 more source

Prevalence and breed predisposition for thoracolumbar intervertebral disc disease in cats [PDF]

, 2016
Objectives The objective was to evaluate the prevalence and possible breed predilections for thoracolumbar intervertebral disc disease (IVDD) in cats. Methods Medical records and imaging studies of cats diagnosed with thoracolumbar IVDD between January ...
De Decker, S, Volk, H A, Warner, A-S
core   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Sympathetic activity is correlated with satellite cell aging and myogenesis via β2-adrenoceptor

Stem Cell Research & Therapy, 2021
Background and objective Sympathetic activity plays an important role in the proliferation and differentiation of stem cells, and it changes over time, thereby exerting differential effects on various stem cell types.
Shiguo Yuan, Sheng Zheng, Kai Zheng, Yanping Gao, Meixiong Chen, Yikai Li, Xiaochun Bai   +6 more
doaj   +1 more source

Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis [PDF]

, 2007
Background Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and
Brockington, A., Hartley, J., Nixon, H., Shaw, P.J., Wokke, B.   +4 more
core   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Polyethylene microplastics transported to nucleus pulposus cells via macrophages-derived exosomes, and promote intervertebral disc degeneration through NAT10/SLC7A11 and ac4C modification

Ecotoxicology and Environmental Safety
Background: Intervertebral disc degeneration (IVDD) serves as the fundamental pathological basis for low back pain. Microplastics influence the organisms through exosomes-mediated communication.
Weilin Zhang, Kuize Liu, Zhencong Li, Dao Feng, Boyuan Zhou, Wei Zhao, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Siyuan Chen, Yen Wei, Jinsong Wei   +11 more
doaj   +1 more source

MYL3 protects chondrocytes from senescence by inhibiting clathrin-mediated endocytosis and activating of Notch signaling

Nature Communications, 2023
As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte ...
He Cao, Panpan Yang, Jia Liu, Yan Shao, Honghao Li, Pinglin Lai, Hong Wang, Anling Liu, Bin Guo, Yujin Tang, Xiaochun Bai, Kai Li   +11 more
doaj   +1 more source

Blindness incidence in Germany - A population-based study from Württemberg-Hohenzollern [PDF]

, 1999
Few data on the incidence of blindness in Germany are available. We analysed causes of legal blindness for the region Württemberg-Hohenzollern (population 5.5 million) in order to help fill in this gap.
Klauss, V., Krumpaszky, H. G., Lüdtke, R., Mickler, A., Selbmann, H. K.   +4 more
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source