Results 71 to 80 of about 4,732,020 (409)
Nature Communications, 2023 As the unique cell type in articular cartilage, chondrocyte senescence is a crucial cellular event contributing to osteoarthritis development. Here we show that clathrin-mediated endocytosis and activation of Notch signaling promotes chondrocyte ...
He Cao +11 more
doaj +1 more source
Large Language Models for Biomedical Knowledge Graph Construction: Information extraction from EMR notes [PDF]
, 2023 The automatic construction of knowledge graphs (KGs) is an important research area in medicine, with far-reaching applications spanning drug discovery and clinical trial design. These applications hinge on the accurate identification of interactions among medical and biological entities. In this study, we propose an end-to-end machine learning solution
arxiv +1 more source
Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. [PDF]
, 2016 The main pathogenesis of intervertebral disc (IVD) herniation involves disruption of the annulus fibrosus (AF) caused by ageing or excessive mechanical stress and the resulting prolapse of the nucleus pulposus.
Asahara, Hiroshi +14 more
core +1 more source
Orthopaedic Surgery, 2022 Objective To investigate the changes in proinflammatory cytokines and chemokines, namely, C‐C motif ligand (CCL) 2 and CCL7, in postmenopausal osteoporosis (PMOP) and to develop a new drug, bindarit (Bnd), for PMOP in an ovariectomized (OVX) mouse model.
Shi‐guo Yuan +6 more
doaj +1 more source
Compete to Win: Enhancing Pseudo Labels for Barely-supervised Medical Image Segmentation [PDF]
, 2023 This study investigates barely-supervised medical image segmentation where only few labeled data, i.e., single-digit cases are available. We observe the key limitation of the existing state-of-the-art semi-supervised solution cross pseudo supervision is the unsatisfactory precision of foreground classes, leading to a degenerated result under barely ...
arxiv +1 more source
Prevalence of age-related macular degeneration in Nakuru, Kenya: a cross-sectional population-based study. [PDF]
, 2013 BACKGROUND: Diseases of the posterior segment of the eye, including age-related macular degeneration (AMD), have recently been recognised as the leading or second leading cause of blindness in several African countries.
Bastawrous, Andrew +5 more
core +6 more sources
Bone & Joint ResearchAims: This study aimed to explore the biological and clinical importance of dysregulated key genes in osteoarthritis (OA) patients at the cartilage level to find potential biomarkers and targets for diagnosing and treating OA. Methods: Six sets of gene
Di Zhao +9 more
doaj +1 more source
Submicron-Grooved Films Modulate the Directional Alignment and Biological Function of Schwann Cells
Journal of Functional Biomaterials, 2023 Topographical cues on material surfaces are crucial for guiding the behavior of nerve cells and facilitating the repair of peripheral nerve defects. Previously, micron-grooved surfaces have shown great potential in controlling nerve cell alignment for ...
Zhen Zhang +8 more
doaj +1 more source
A variance components factor model for genetic association studies: a Bayesian analysis.
, 2010 Studies of gene-trait associations for complex diseases often involve multiple traits that may vary by genotype groups or patterns. Such traits are usually manifestations of lower-dimensional latent factors or disease syndromes.
Nonyane, BAS, Whittaker, JC
core +1 more source
Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome. [PDF]
, 2018 PurposeTo evaluate the relationship between retinal vascular caliber and AMD in patients with AIDS.MethodsParticipants enrolled in the Longitudinal Study of the Ocular Complications of AIDS had retinal photographs taken at enrollment.
Danis, Ronald P +4 more
core +1 more source