Results 91 to 100 of about 159,239 (309)

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Distribution of lactate dehydrogenase in healthy and degenerative canine stifle joint cartilage [PDF]

, 2018
In dogs, degenerative joint diseases (DJD) have been shown to be associated with increased lactate dehydrogenase (LDH) activity in the synovial fluid. The goal of this study was to examine healthy and degenerative stifle joints in order to clarify the ...
Friess, Armin, Schawalder, Peter, Schmöckel, Hugo, Spreng, David, Stoffel, Michael, Tschudi, Peter, Walter, Eveline   +6 more
core  

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

Evaluating elbow osteoarthritis within the prehistoric Tiwanaku state using generalized estimating equations (GEE). [PDF]

, 2019
OBJECTIVES:Studies of osteoarthritis (OA) in human skeletal remains can come with scalar problems. If OA measurement is noted as present or absent in one joint, like the elbow, results may not identify specific articular pathology data and the sample ...
Bass W. M., Brothwell D. R., Buikstra J. E., Dieppe P., Felson D., Gagnon C. M., Gagnon C. M., Goldstein P. S., Goldstein P. S., Goodman A. H., Hunter D., Iscan M. Y., Janusek J. W., Jurmain R., Krogman W., Pearson O. M., Rogers J., Suchey J. M., Suchey J. M., Ubelaker D. H., Verano J., White T. D.   +21 more
core   +1 more source

A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions

Advanced Science, EarlyView.
This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies, Emanuele Nicotra, Kefan Zhu, Chi Cong Nguyen, Bibhu Sharma, Adrienne Ji, Phuoc Thien Phan, Jingjing Wan, Patrick Pruscino, Hermione Truong, Jelena Rnjak‐Kovacina, Hoang‐Phuong Phan, Christopher Hayward, Nigel Hamilton Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Temporomandibular degenerative joint disease

Oral Surgery, Oral Medicine, Oral Pathology, 1975
Oral Surgery, Oral Medicine, Oral Pathology 40 (1975) 297-319.
University of Florida College of Dentistry Gainesville, Fla., USA ( host institution ), Kreutziger, Keith L., Mahan, Parker E.   +2 more
openaire   +3 more sources

Relationship of the medial clavicular head to the manubrium in normal and symptomatic degenerated sternoclavicular joints [PDF]

, 2014
Background: Clavicular prominence is common in patients with symptomatic degenerative sternoclavicular arthritis. It is unclear if this is caused by enlargement or subluxation of the clavicle.
De Wilde, Lieven, Piepers, Iwein, Valcke, Jens, Van Tongel, Alexander, Verschueren, Thomas   +4 more
core   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Shoulder pain due to cervical radiculopathy: an underestimated long-term complication of herpes zoster virus reactivation? [PDF]

, 2018
Purpose To evaluate if herpes zoster virus (HZV) reactivation may be considered in the aetiology of cervical radiculopathy. Methods The study group was composed of 110 patients (52 M-58F;mean age ± SD:46.5 ± 6.12; range:40-73) with a clinical ...
AS Hilibrand, B Kuijper, Ciro Villani, DA Perez-Martienz, Daniele Passaretti, DH Gilden, E Viikari-Juntura, H Sandmark, HC Tong, I Steiner, JP Makela, K Radhakrishnan, KC Shah, KM Abbed, MC Sanchez, MM Ban Le, MM Vargo, MT Modic, MT Modic, NA Peterslund, PG Kennedy, PW Detwiler, R Atkinson, RE Yoss, RS Wainner, RW Johnson, S Gumina, S Shabat, Stefano Gumina, T Fujy, Vittorio Candela, W Frobin, W Frobin, W Frobin, Y Uematsu   +34 more
core   +1 more source