Results 91 to 100 of about 6,731,159 (297)

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Enomoto_Development_of_FMPC-_R1_-_Supplemental_File_1 – Supplemental material for Development of a checklist for the detection of degenerative joint disease-associated pain in cats

, 2020
Supplemental material, Enomoto_Development_of_FMPC-_R1_-_Supplemental_File_1 for Development of a checklist for the detection of degenerative joint disease-associated pain in cats by Masataka Enomoto, B Duncan X Lascelles and Margaret E Gruen in Journal ...
Masataka Enomoto (3693328), B Duncan X Lascelles (5548316), Margaret E Gruen (8530347)   +2 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

PAGET'S DISEASE INVOLVING THE HIP JOINT

, 1971
1. The early signs of Paget's disease of the acetabulum and femur are described. 2. The pattern of arthritis is presented in 199 hips in which Paget's disease of bone occurred in either the femur, the acetabulum or both bones.
William H. Harris, James Graham
core   +1 more source

Enomoto_Development_of_FMPC-_R1_-_Supplemental_File_2 – Supplemental material for Development of a checklist for the detection of degenerative joint disease-associated pain in cats

, 2020
Supplemental material, Enomoto_Development_of_FMPC-_R1_-_Supplemental_File_2 for Development of a checklist for the detection of degenerative joint disease-associated pain in cats by Masataka Enomoto, B Duncan X Lascelles and Margaret E Gruen in Journal ...
Masataka Enomoto (3693328), B Duncan X Lascelles (5548316), Margaret E Gruen (8530347)   +2 more
core   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery

Materials Today Bio
Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological ...
Runzi Guo, Zhenzhen Zhang, Shuyi Zhang, Tingting Gai, Huizhu Yu, Li Su, Heng Yin, Xiuhui Wang, Yafeng Zhang   +8 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

An assessment of degenerative joint disease of the hip and shoulder in a Cypriot community from Limassol, Cyprus [PDF]

, 2016
Degenerative joint disease (DJD) is one of the most common pathological conditions observed in skeletal collections. DJD is the destruction of articular cartilage and bone at the joint surface.
Rodriguez, Lizette
core