Results 101 to 110 of about 159,239 (309)

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Correlation between pain and degenerative bony changes on cone-beam computed tomography images of temporomandibular joints

Maxillofacial Plastic and Reconstructive Surgery, 2017
Background The aim of this study was to assess correlation between pain and degenerative bony changes on cone-beam computed tomography (CBCT) images of temporomandibular joints (TMJs).
SunMee Bae, Moon-Soo Park, Jin-Woo Han, Young-Jun Kim   +3 more
doaj   +1 more source

Unusual presentation of an avulsion of the long digital extensor tendon in a dog: radiographic, computed tomographic, arthroscopic, surgical and histological findings [PDF]

, 2007
A long digital extensor tendon avulsion is reported in a 15-month-old intact male Great Dane with a right pelvic limb lameness of 2-week duration. The orthopedic, radiographic, computed tomographic, arthroscopic, surgical and histological findings are ...
Gielen, Ingrid, Risselada, Marije, van Bree, Henri, Van Ryssen, Bernadette, Verhoeven, Geert   +4 more
core  

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

The potential for dietary factors to prevent or treat osteoarthritis [PDF]

, 2014
Osteoarthritis (OA) is a degenerative joint disease for which there are no disease-modifying drugs. It is a leading cause of disability in the UK. Increasing age and obesity are both major risk factors for OA and the health and economic burden of this ...
Bao, Yongping, Cassidy, Aedín, Clark, Ian M., Davidson, Rose K., Donell, Simon T., Green, Jonathan A., Hirst-Jones, Kimberley L., Jupp, Orla, Macgregor, Alexander J.   +8 more
core   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Innovative nanocarriers: Synthetic and biomimetic strategies for enhanced drug delivery

Materials Today Bio
Effective drug delivery plays a vital role in the treatment of various biomedical conditions. Application of innovative nanocarriers could address issues faced in drug delivery such as poor drug distribution, inefficient penetration across biological ...
Runzi Guo, Zhenzhen Zhang, Shuyi Zhang, Tingting Gai, Huizhu Yu, Li Su, Heng Yin, Xiuhui Wang, Yafeng Zhang   +8 more
doaj   +1 more source

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg, Antonacci, Christopher L, Kepler, Chris K, Koerner, John D, Markova, Dessislava Z, Mendelis, Joseph, Schroeder, Greg D, Vaccaro, Alexander R   +7 more
core   +1 more source

A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
Upon NIR irradiation at 808 nm, the activity of TRPV4 was inhibited by M2M@BPSC, which led to reduced calcium influx, mitochondrial protection, and, importantly, the transcriptional activation of the STAT6‐EGR2 pathway. The improved macrophage function indirectly readjusts the equilibrium between C‐ECM and F‐ECM to reconstruct a suitable ...
Chenqi Yu, Yang Liu, Kang Kang, Jianfeng Yu, Xiaowei Xia, Yaoge Deng, Yingjie Lu, Huilin Yang, Lisong Li, Wu Xu, Yijian Zhang, Xuesong Zhu   +11 more
wiley   +1 more source

Occurrence and Regional Distribution of TRAIL and DR5 on Temporomandibular Joint Discs: Comparison of Disc Derangement with and without Reduction [PDF]

, 2010
Background Tumor necrosis factor (TNF)–related apoptosis-inducing ligand (TRAIL) is an apoptosis-inducing member of the TNF gene family which triggers apoptotic signals by interaction with its receptors.
Almeida, Luis Eduardo, Leonardi, Rosalia, Loreto, Carla, Trevilatto, Paula C.   +3 more
core   +1 more source