Results 111 to 120 of about 6,731,159 (297)

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

open access: yesAdvanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai   +10 more
wiley   +1 more source

Patterns of degenerative change in the glenohumeral joint

open access: yes, 1995
Examination was made of 486 skeletons of subjects over the age of 60 years to study patterns of degenerative change in the glenohumeral joint. Three distinct types were found. Useful clinical implications are drawn from these distinctions.
JG Edelson
core   +1 more source

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin   +23 more
wiley   +1 more source

Kvaliteta života osoba oboljelih od psorijatičnoga artritisa u usporedbi s reumatoidnim artritisom i degenerativnom bolešću zglobova [Quality of life in patients with psoriatic arthritis in comparison to rheumathoid arthritis and degenerative joint disease] [PDF]

open access: yes, 2016
Objectives. The main objective of this research is to compare quality of life in patients with PsA with the quality of life with patients suffering from RA and patients suffering from degenerative joint disease and to determine predictors of both ...
Grubišić, Frane
core   +1 more source

Total Mandibular Joint Replacement as a Treatment Modality for Temporomandibular Joint Disorders: A Case Report

open access: yesJournal of Craniomaxillofacial Research
Temporomandibular Joints (TMJ) is a bilateral fibrocartilage joint. This joint is unique in that it is a bilateral joint that functions as one unit. As with the other joints, many conditions affect TMJ causing It not to do its tasks.
Masoud Fallahi Motlagh   +3 more
doaj   +1 more source

Characterisation of the correlation between standing lordosis and degenerative joint disease in the lower lumbar spine in women and men: A radiographic study

open access: yes, 2017
Characterisation of the correlation between standing lordosis and degenerative joint disease in the lower lumbar spine in women and men: A radiographic ...
KJ Murray (14869126)   +3 more
core  

Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation

open access: yesAdvanced Science, EarlyView.
Retrospective grid cells are identified in the medial entorhinal cortex, with spatial firing patterns that become most grid‐like when activity is projected onto recently traversed locations. Their coding loses spatial precision in darkness and is disrupted during assisted movement, indicating that entorhinal representations incorporate recent path ...
Ruojin Liu   +10 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

open access: yesAdvanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He   +7 more
wiley   +1 more source

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