Results 21 to 30 of about 4,421 (195)

Liver Fat Changes in Patients With Type 2 Diabetes by Presence of Genetic Hepatic Steatosis: A Post Hoc Analysis of SURPASS-3 MRI. [PDF]

Liver Int
ABSTRACT The patatin‐like phospholipase 3 (PNPLA3) I148M genetic variant is highly associated with steatotic liver disease. In the SURPASS‐3 MRI substudy, tirzepatide significantly reduced liver fat content (LFC) versus insulin degludec in insulin‐naïve patients with type 2 diabetes with metabolic dysfunction‐associated steatotic liver disease.
Cusi K, Gastaldelli A, Landó LF, Sharma P, Torcello-Gómez A, Rodríguez Á.   +5 more
europepmc   +2 more sources

Rapid quantification of insulin degludec by immunopurification combined with liquid chromatography high-resolution mass spectrometry. [PDF]

, 2020
Insulin degludec is an ultra-long-acting insulin analogue that is increasingly being used in diabetes due to its favourable efficacy and safety profile. Thus, there is an increasing demand for a reliable and specific analytical method to quantify insulin
Prost, Jean-Christophe, Reverter-Branchat, Gemma, Bally, Lia, Niederkofler, Eric E, Antwi, Kwasi, Groessl, Michael, Nakas, Christos T   +6 more
core   +3 more sources

Efficacy and Safety of iGlarLixi Versus IDegAsp by Baseline Age, Disease Duration and HbA1c in Chinese People With Type 2 Diabetes: Post Hoc Analyses of the Soli-D Study. [PDF]

Diabetes Obes Metab
ABSTRACT Aims To compare the efficacy and safety of insulin glargine 100 U/mL plus lixisenatide (iGlarLixi) with insulin degludec plus insulin aspart (IDegAsp) by baseline age, Type 2 diabetes (T2D) duration and glycated haemoglobin (HbA1c) in the Soli‐D study.
Zhang S, Gu Y, Cheng Y, Hu Y, Li B, Alvarez A, Lauand F, Melas-Melt L, Zhang M, Jiang Y, Du Q, Kang L, Mu Y, Gu W, Kuang H.   +14 more
europepmc   +2 more sources

Insulin Efsitora Demonstrates Similar Efficacy and Safety Profiles to Insulin Icodec in Insulin-Experienced Individuals With Type 2 Diabetes Mellitus: Matching-Adjusted Indirect Comparisons of QWINT-3 Versus ONWARDS 2, and QWINT-4 Versus ONWARDS 4. [PDF]

Diabetes Obes Metab
ABSTRACT Aims To conduct indirect treatment comparisons (ITCs) of insulin efsitora alfa (efsitora) versus insulin icodec (icodec) in insulin‐experienced individuals with Type 2 Diabetes Mellitus. Methods Efficacy, safety and patient reported outcomes were compared via matching‐adjusted ITCs using results from randomised controlled trials: QWINT‐3 ...
Bajaj HS, Fischer M, Davidson MB, Tarafder AM, Michaels CJ, Tao RH, Pashley A, Amis J, Redig J.   +8 more
europepmc   +2 more sources

Giant abdominal hematoma from injection into an insulin ball during dual antithrombotic and corticosteroid therapy. [PDF]

J Diabetes Investig
Journal of Diabetes Investigation, EarlyView.
Tanji Y, Komamura H, Mita T, Sawada S.
europepmc   +2 more sources

Considerations for the Integration of Clinical Trials and Real‐World Data [PDF]

Clin Pharmacol Ther
As clinical decision‐making increasingly moves toward individualized and context‐specific treatment recommendations, reliance on any single evidence source, randomized or observational, may be insufficient. Principled integration of randomized controlled trials and real‐world data, grounded in explicit causal frameworks, offers a path toward evidence ...
Qiu S, Barr C, Dang L, Han L, Kvist K, Lee H, Mertens A, Nance N, Nie L, Rudolph K, Shi X, Tarp J, Waddy S, Wiley K, Wilson A, Yann M, Zhang Z, Zhou T, Petersen M, van der Laan M.   +19 more
europepmc   +2 more sources

Insulin Degludec/Liraglutide [PDF]

Hospital Pharmacy, 2017
Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing ...
openaire   +2 more sources

Effectiveness and safety of flexible therapeutic schemes including first- and secondgeneration basal insulins during a pediatric summer diabetes camp

Pediatric Reports, 2020
Outcomes of insulin analogues in pediatric diabetes camps are poorly investigated; no data is available about insulin degludec (IDeg).Our aim was to assess impact of insulin therapy adopted by the participants to a 4-day diabetes camp held in 2017 ...
Stefano Tumini, Laura Comegna, Elisabetta Fioretti, Paola Guidone, Gabriella Levantini, Daniele Panichi, Milena Catenaro, Ilaria Rossi, Flavia Amaro, Giusi Graziano, Maria Chiara Rossi, Paola Cipriano   +11 more
doaj   +1 more source

Flexibility in insulin prescription

Indian Journal of Endocrinology and Metabolism, 2016
This communication explores the concept of flexibility, a propos insulin preparations and insulin regimes used in the management of type 2 diabetes.
Sanjay Kalra, Yashdeep Gupta, Ambika Gopalakrishnan Unnikrishnan   +2 more
doaj   +1 more source

Insulin/carbohydrates ratio during the first 6‐month therapy with insulin degludec in a paediatric population with type 1 diabetes previously treated with insulin glargine. An observational longitudinal study

Endocrinology, Diabetes & Metabolism, 2020
Background No data exist about the changes induced by the transition from first‐generation long‐acting insulins to second‐generation long‐acting analogues in the paediatric population.
Stefano Tumini, Olimpia Iacono, Laura Comegna, Elisabetta Fioretti, Paola Guidone, Gabriella Levantini, Daniele Panichi, Milena Catenaro, Ilaria Rossi, Flavia Amaro, Giusi Graziano, Maria Chiara Rossi, Paola Cipriano   +12 more
doaj   +1 more source