Results 11 to 20 of about 4,101,114 (282)

A Multi-Scenario Prediction and Spatiotemporal Analysis of the Land Use and Carbon Storage Response in Shaanxi

Remote Sensing, 2023
The role of carbon sequestration in terrestrial ecosystems is crucial for achieving carbon neutrality. This study primarily focuses on examining the carbon storage in Shaanxi Province under different land-use scenarios.
Xindong Wei, Shuyuan Zhang, Pingping Luo, Shuomeng Zhang, Huanyuan Wang, Dehao Kong, Yuanyuan Zhang, Yang Tang, Shuo Sun   +8 more
doaj   +1 more source

Methods to Detect AUTOphagy-Targeting Chimera (AUTOTAC)-mediated Targeted Protein Degradation in Tauopathies

Bio-Protocol, 2023
Targeted protein degradation (TPD) facilitates the selective elimination of unwanted and pathological cellular cargoes via the proteasome or the lysosome, ranging from proteins to organelles and pathogens, both within and outside the cell.
Min Lee, Su Kim, Hee Kim, Su Jin Lee, Ji Su Lee, Yong Tae Kwon, Chang Ji   +6 more
doaj   +1 more source

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]

, 2011
Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham, Anna M. Salazar, Chen, Ciechanover, Clark, Cox, David C. Chan, de Godoy, Deng, Deshaies, Ding, Gautier, Gegg, Geisler, Greene, Griparic, Kirkpatrick, Korolchuk, Kuroda, Lee, Matsuda, Michael J. Sweredoski, Narendra, Narendra, Narendra, Narendra, Natalie J. Kolawa, Nickie C. Chan, Okatsu, Ong, Pagliarini, Palacino, Pallanck, Park, Poole, Poole, Rappsilber, Robert L.J. Graham, Shimura, Song, Sonja Hess, Sou, Tai, Tanaka, Twig, Vives-Bauza, Yang, Yao, Ziviani, Ziviani   +49 more
core   +3 more sources

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Journal of Hematology & Oncology, 2016
Background Acquired imatinib (IM) resistance is frequently characterized by Bcr-Abl mutations that affect IM binding and kinase inhibition in patients with chronic myelogenous leukemia (CML).
Xiaoying Lan, Chong Zhao, Xin Chen, Peiquan Zhang, Dan Zang, Jinjie Wu, Jinghong Chen, Huidan Long, Li Yang, Hongbiao Huang, Bing Z. Carter, Xuejun Wang, Xianping Shi, Jinbao Liu   +13 more
doaj   +1 more source

Analysis of Scarp Profiles: Evaluation of Errors in Morphologic Dating [PDF]

, 1993
Morphologic analysis of scarp degradation can be used quantitatively to determine relative ages of different scarps formed in cohesionless materials, under the same climatic conditions.
Avouac, Jean-Philippe
core   +1 more source

Downregulation of Linc00173 increases BCL2 mRNA stability via the miR-1275/PROCA1/ZFP36L2 axis and induces acquired cisplatin resistance of lung adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2023
Background LINC00173 had been reported as a cisplatin (cis-diamminedichloroplatinum, DDP) chemotherapy-resistant inducer in small-cell lung cancer (SCLC) and lung squamous cell carcinoma (LUSC). This study aimed to display reverse data for LINC00173 as a
Xingyu Tao, Yang Li, Songqing Fan, Liyang Wu, Jianyang Xin, Yun Su, Xiaoyang Xian, Yingying Huang, Rongquan Huang, Weiyi Fang, Zhen Liu   +10 more
doaj   +1 more source

Crushing behaviour of composite square honeycomb structure: a finite element analysis

Journal of Mechanical Engineering and Sciences, 2017
This paper investigates the compression properties of square honeycomb core materials based on glass fibre reinforced plastic. The objective of this project is to determine the failure strength and energy absorption of the square honeycomb structure and ...
Z. Ansari, C.W. Tan, M.R.M. Rejab, D. Bachtiar, J. Siregar, M.Y.M. Zuhri, N.S.D.M. Marzuki   +6 more
doaj   +1 more source

A Novel Vegetation Index Approach Using Sentinel-2 Data and Random Forest Algorithm for Estimating Forest Stock Volume in the Helan Mountains, Ningxia, China

Remote Sensing, 2023
Forest stock volume (FSV) is a major indicator of forest ecosystem health and it also plays an important part in understanding the worldwide carbon cycle.
Taiyong Ma, Yang Hu, Jie Wang, Mukete Beckline, Danbo Pang, Lin Chen, Xilu Ni, Xuebin Li   +7 more
doaj   +1 more source

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation. [PDF]

, 2019
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasomes regulatory particle, consisting of lid
Aufderheide, Bard, Bard, Bard, Bashore, Beckwith, Dambacher, de la Peña, Ding, Dong, Eisele, Elsasser, Finley, Glickman, Glickman, Goldstein, Groll, Hershko, Kachroo, Lander, Lasker, Longtine, Matyskiela, Myers, Nemec, Peth, Prakash, Rubin, Smith, Sone, Tomko, Unverdorben, Verma, VerPlank, VerPlank, Wehmer, Wendler, Wenzel, Worden, Worden, Yao, Zhu, Śledź   +42 more
core   +1 more source

Design of portable 3-axis filament winding machine with inexpensive control system

Journal of Mechanical Engineering and Sciences, 2018
Filament winding technology is one of the fundamental fabrication methods in composite material fields, which has a high degree of automation. It is the process in which continuous strands or filament of fibres is wound on the mandrel, which is suitable ...
Ma Quanjin, M.R.M.Rejab, I.M. Sahat, M. Amiruddin, D. Bachtiar, J.P. Siregar, M.I. Ibrahim   +6 more
doaj   +1 more source