Results 31 to 40 of about 2,374,007 (316)

"TO THE DEGRADATION OF THE SPECTATOR." [PDF]

The Lancet, 1896
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openaire   +2 more sources

Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders

Nature Communications
The ubiquitin E3 ligase cereblon (CRBN) is the target of therapeutic drugs thalidomide and lenalidomide and is recruited by most targeted protein degraders (PROTACs and molecular glues) in clinical development. Biophysical and structural investigation of
Alena Kroupova, Valentina A. Spiteri, Zoe J. Rutter, Hirotake Furihata, Darren Darren, Sarath Ramachandran, Sohini Chakraborti, Kevin Haubrich, Julie Pethe, Denzel Gonzales, Andre J. Wijaya, Maria Rodriguez-Rios, Manon Sturbaut, Dylan M. Lynch, William Farnaby, Mark A. Nakasone, David Zollman, Alessio Ciulli   +17 more
doaj   +1 more source

Development of an oncogenic dedifferentiation SOX signature with prognostic significance in hepatocellular carcinoma

BMC Cancer, 2019
Background Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression.
Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma, Ming Liu   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Method for quantification of microplastic release from plastic-based materials during weathering

Microplastics and Nanoplastics
Most microplastics (MPs) are generated as a result of photodegradation during the life of plastic products and after the end-of-life as mismanaged waste.
Edgars Kuka, Ingeborga Andersone, Dace Cirule, Lotars Olivers Vasiljevs, Anrijs Verovkins, Errj Sansonetti, Galina Dobele, Bruno Andersons   +7 more
doaj   +1 more source

Structure Characterization and Electrical Properties of Sn0.9Ga0.1P2O7/KH2PO4/KPO3 Composite Electrolyte for Medium Temperature Fuel Cells

International Journal of Electrochemical Science, 2020
In this study, Sn0.9Ga0.1P2O7/KH2PO4/KPO3 was synthesized by solid-phase method. The sample was characterized by Raman spectrometer and X-ray diffractometer.
Yan Han, Zikun Rong, Tianhui Hu, Peng Sun, Lin Sun, Hui Miao   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Facile Preparation of Cu2+-doped Tin(IV) Pyrophosphate /Potassium Metaphosphate Composite as a Highly Efficient Electrolyte for Intermediate Temperature SOFCs

International Journal of Electrochemical Science, 2020
In this study, a Sn0.95Cu0.05P2O7/KPO3 composite ceramic was synthesized via a facile solid state reaction method and characterized by X-ray diffractometer (XRD), scanning electron microscopy (SEM) and Raman spectroscopy.
RuijuanShi, Jingjing Zhu, Peng Sun, Nan Wang, Junlong Liu, Hongtao Wang   +5 more
doaj   +1 more source

Mild‐Photothermal Effect Induced High Efficiency Ferroptosis‐Boosted‐Cuproptosis Based on Cu2O@Mn3Cu3O8 Nanozyme

Advanced Science, 2023
A core‐shell‐structured Cu2O@Mn3Cu3O8 (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)‐activated copper ionophore to achieve safe and efficient cuproptosis.
Wei Chen, Wenyu Xie, Zhimin Gao, Chen Lin, Meiling Tan, Yaru Zhang, Zhiyao Hou   +6 more
doaj   +1 more source

A Survey of the Modeling and Application on Non-destructive and Destructive Degradation Tests

, 2017
These days, most products are highly reliable which makes it very difficult or even impossible to obtain failure data on such products within a reasonable period of time prior to product release. Degradation tests are one way to overcome this obstacle by
Chih-Chun Tsai, N. Balakrishnan, Tsai, Chih-chun, Chien-Tai Lin   +3 more
core   +1 more source