Results 51 to 60 of about 2,986,953 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The performance of mengkuang leaf fiber reinforced low density polyethylene composites

Journal of Mechanical Engineering and Sciences, 2018
The performance of mengkuang leaf fiber (MLF) reinforced low density polyethylene (LDPE) composites with different fiber volume and different mesh sizes were studied.
N.A. Halim, J.P. Siregar, D. Mathivanan, D. Bachtiar, Z. Ghazali, M.R.M Rejab, T. Tezara   +6 more
doaj   +1 more source

Forecasting linear aliphatic copolyester degradation through modular block design

, 2016
The development of efficient methods to predict the degradation of renewable polymeric materials is continuously sought in the field of polymer science.
Odelius, Karin,, Arias, Veluska,, Albertsson, Ann-Christine,, Höglund, Anders,, Olsén, Peter,   +4 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Novel Composite Electrolyte of Double-Doped Ceria-Sulphate for Medium Temperature Fuel Cells

International Journal of Electrochemical Science, 2020
In this study, Gd3+ and Er3+ double-doped CeO2 was synthesized by a microemulsion method. Ce0.8Er0.1Gd0.1O2-α-K2SO4-Li2SO4 composite electrolyte was prepared by mixing Ce0.8Er0.1Gd0.1O2-α powder with binary sulphates.
Wenbao Zhang, Tianhui Hu, Ruijuan Shi, Hongtao Wang   +3 more
doaj   +1 more source

Tenascin-C fragments are endogenous inducers of cartilage matrix degradation [PDF]

, 2011
Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity.
Hermansson, M, Saralili Dipa Robertson, Wait, R, Robertson, SD, Wait, Robin, Monika Hermansson, Jonathan Jones, Philip Mitchell, Mitchell, P, Sofat, N, Nidhi Sofat, Jones, J, Robin Wait   +12 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

CHLOROPHYLL DEGRADATION

Annual Review of Plant Physiology and Plant Molecular Biology, 1999
▪ Abstract  Although the loss of green color in senescent leaves and ripening fruits is a spectacular natural phenomenon, research on chlorophyll breakdown has been largely neglected until recently. This review summarizes knowledge about the fate of chlorophyll in degreening tissues that has been gained during the past few years. Structures of end- and
Matile P, Hortensteiner S, Thomas H
openaire   +3 more sources