Results 61 to 70 of about 2,374,007 (316)

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

CHLOROPHYLL DEGRADATION

Annual Review of Plant Physiology and Plant Molecular Biology, 1999
▪ Abstract  Although the loss of green color in senescent leaves and ripening fruits is a spectacular natural phenomenon, research on chlorophyll breakdown has been largely neglected until recently. This review summarizes knowledge about the fate of chlorophyll in degreening tissues that has been gained during the past few years. Structures of end- and
Matile P, Hortensteiner S, Thomas H
openaire   +3 more sources

Variations in the quantity and chemical composition of soil dissolved organic matter along a chronosequence of wolfberry plantations in an arid area of Northwest China

Chemical and Biological Technologies in Agriculture
Background Dissolved organic matter (DOM) is the most active component of soil organic matter (SOM), playing a major role in regulating soil fertility and carbon cycling.
Rongjie Wu, Bin Xue, George Martial Ndzana, Yan Wang, Longwei Fu, Bingqing Liu, Ruili Gao, Kun Ma, Lingtong Du, Hui An, Muhammad Kamran   +10 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Low Temperature Synthesis of SrCe0.9Eu0.1O3-α by Sol-Gel Method and SrCe0.9Eu0.1O3-α-NaCl-KCl Composite Electrolyte for Intermediate Temperature Fuel Cells

International Journal of Electrochemical Science, 2017
SrCe0.9Eu0.1O3-α (SCEu-SG) electrolyte was prepared via the sol-gel method at a low heat-treating temperature of 1100 oC. The transport properties of SCEu-SG are studied using gas concentration cells.
Ruijuan Shi, Junlong Liu, Hongtao Wang, Fufang Wu, Hui Miao, Yumin Cui   +5 more
doaj   +1 more source

LC-MS analysis of the degradation products of a sprayable, biodegradable poly(ester-urethane-urea)

, 2022
Art.109218Biodegradable polymers must degrade completely to CO2, H2O, small and non-toxic molecules (e.g. NO3− and NH3/NH4+), and biomass on a similar timescale to classically compostable materials (3-12 months).
Borrowman, C.K., Adhikari, R., Patti, A.F., Bücking, M., Saito, K., Göckener, B.   +5 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A new gold(I) complex-Au(PPh3)PT is a deubiquitinase inhibitor and inhibits tumor growthResearch in context

EBioMedicine, 2019
Background: Ubiquitin-proteasome system (UPS) is integral to cell survival by maintaining protein homeostasis, and its dysfunction has been linked to cancer and several other human diseases.
Xiaofen Li, Qingtian Huang, Huidan Long, Peiquan Zhang, Huabo Su, Jinbao Liu   +5 more
doaj   +1 more source