Results 81 to 90 of about 4,145,184 (301)

Thermal Degradation on Already Oxidatively Degraded Solutions

Energy Procedia, 2013
AbstractCO2 capture with alkanolamines has been in use since 1930, where 2-ethanolamine (MEA) is the most studied absorbent for post-combustion. In order to prevent degradation, it is important to understand the degradation mechanisms, which in turn requires knowledge of both stoichiometry and kinetics of the reactions and chemical pathways associated ...
Vevelstad, Solrun Johanne, Grimstvedt, Andreas Magnar, Knuutila, Hanna, Svendsen, Hallvard Fjøsne   +3 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Advanced Science
Uncontrolled degradation of wound dressings may result in residues, causing several negative effects on wound healing, such as secondary damage, undesirable inflammation, and scar skin formation.
Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen   +7 more
doaj   +1 more source

Study of the Electrical Conductivity of Al(III) Doped Sr0.6Na0.4SiO3-a

International Journal of Electrochemical Science, 2019
Sr1-xNaxSiO3-0.5x is receiving worldwide attention as the fast oxide ion conductor. Sr0.6Na0.4Si0.9Al0.1O3- a and Sro.6Nao.4SiO3—α were successfully fabricated using a solid state synthesis method and characterized with X-ray diffractometer (XRD) and ...
Ruijuan Shi, Ruifeng Du, Junlong Liu, Hongtao Wang   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Facile Synthesis and Enhanced Intermediate Temperature Electrical Properties of Novel Sn0.9Mg0.1P2O7/KSn2(PO4)3 Composite Electrolyte

International Journal of Electrochemical Science, 2018
The application of Sn1-xMxP2O7 electrolyte for solid oxide fuel cells is limited due to its poor sintering abilities. In this study, a new Sn0.9Mg0.1P2O7/KSn2(PO4)3 composite electrolyte was facile synthesized and the structural and microstructural ...
Junlong Liu, Ruifeng Du, Ruijuan Shi, Hongtao Wang   +3 more
doaj   +1 more source