Results 71 to 80 of about 1,180,459 (201)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Oxidative degradation of polylactide (PLA) and its effects on physical and mechanical properties [PDF]

, 2014
The thermo-oxidative degradation of polylactide (PLA) films was studied between 70 and 150 C. It was shown that the oxidative degradation of PLA leads to a random chain cission responsible for a reduction of the molar mass.
SOLLOGOUB, Cyrille, MIQUELARD-GARNIER, Guillaume, RUELLAN, Alexandre, RASSELET, Damien, FAYOLLE, Bruno, GUINAULT, Alain   +5 more
core   +1 more source

Integrated machine learning identifies biomarkers for bilirubin-induced Alzheimer’s disease-like lesions in neonates and adults

Scientific Reports
Neurological impairments resulting from bilirubin encephalopathy represent a hallmark of bilirubin’s neurotoxic effects. Earlier research suggests that bilirubin may contribute to Alzheimer’s disease (AD) pathology by inducing neuronal necrosis and ...
Wenhao Bao, Han Chen, Zhuojun Zhang, Jiawen Wu, Jiaqian Lin, Daolin Tang, Jinbao Liu   +6 more
doaj   +1 more source

An efficient bacterial laccase-mediated system for polyurethane foam degradation

Frontiers in Microbiology
Polyurethane (PU), a segmented block copolymer with chemically resistant urethane linkages and tunable architecture, presents persistent biological recycling challenges. This study presents a Bacterial Laccase-Mediated System (BLMS) derived from Bacillus
Xiaomin Zhu, Youren Duan, Jianqi Lu, Wei Xia, Yujia Peng, Jiawei Liu, Weiliang Dong, Weiliang Dong, Min Jiang, Min Jiang   +9 more
doaj   +1 more source

Evaluating applicability of multi-source precipitation datasets for runoff simulation of small watersheds: a case study in the United States

European Journal of Remote Sensing, 2020
Small watersheds are ideal objects for studying the evolution of hydrological and water resources at small scales. Whether precipitation products can meet the runoff simulation of small watersheds is the main purpose of this study.
Kepeng Feng, Yang Hong, Juncang Tian, Xiangyu Luo, Guoqiang Tang, Guangyuan Kan   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tenascin-C fragments are endogenous inducers of cartilage matrix degradation [PDF]

, 2011
Cartilage destruction is a hallmark of osteoarthritis (OA) and is characterized by increased protease activity resulting in the degradation of critical extracellular matrix (ECM) proteins essential for maintaining cartilage integrity.
Hermansson, M, Saralili Dipa Robertson, Wait, R, Robertson, SD, Wait, Robin, Monika Hermansson, Jonathan Jones, Philip Mitchell, Mitchell, P, Sofat, N, Nidhi Sofat, Jones, J, Robin Wait   +12 more
core   +1 more source

A Single-Cell-Derived CD8+ T-Cell State Plasticity Score for Prognostic Stratification and Characterization of Immune Responsiveness in Hepatocellular Carcinoma

ImmunoTargets and Therapy
Le Xing,1,2,* Dan He,2,* Dong-Mei Li,2,* Zhong Liang,2 Chen Yue,2 Cheng-Yang Zhang,2 Ying-Chen Hou,2 Chen-Yu Jiang,2 Guang-Ding Zhou,2 Hongjiao Yu,3,4 Yan-Ling Zhang,5 Yan-Xia Shi,6 Lin-Hai Li,1 Ming Liu1,21Department of ...
Xing L, He D, Li DM, Liang Z, Yue C, Zhang CY, Hou YC, Jiang CY, Zhou GD, Yu H, Zhang YL, Shi YX, Li LH, Liu M   +13 more
doaj  

PGRP-SC–mediated innate immune memory against pathogenic bacteria in Drosophila

hLife
Trained immunity is essential for innate immune cells to retain a memory of previously encountered pathogens, strengthening the hosts’ response against these pathogens. However, the mechanisms governing trained immunity have not been well elucidated.
Zihao Deng, Jiazhen Luo, Yufu Zhang, Chen Li, Shixin Deng, Jiazhi He, Zihao He, Wenqi Wu, Renjie Jiao, Jiyong Liu   +9 more
doaj   +1 more source