Results 41 to 50 of about 1,180,459 (201)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The performance of mengkuang leaf fiber reinforced low density polyethylene composites
Journal of Mechanical Engineering and Sciences, 2018 The performance of mengkuang leaf fiber (MLF) reinforced low density polyethylene (LDPE) composites with different fiber volume and different mesh sizes were studied.
N.A. Halim +6 more
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Degradation of pesticides by the ligninolytic enzyme Laccase [PDF]
, 2013 Pesticides are widely used in many industries but the majority reaches non-target organisms or locations through point or diffuse sources. Understanding conditions for their degradation is therefore important.
Farragher, Naomi
core
Degradation of BTEX by anaerobic bacteria: physiology and application [PDF]
, 2010 Pollution of the environment with aromatic hydrocarbons, such as benzene, toluene, ethylbenzene and xylene (so-called BTEX) is often observed. The cleanup of these toxic compounds has gained much attention in the last decades.
Weelink, S.A.B. +2 more
core +1 more source
Novel Composite Electrolyte of Double-Doped Ceria-Sulphate for Medium Temperature Fuel Cells
International Journal of Electrochemical Science, 2020 In this study, Gd3+ and Er3+ double-doped CeO2 was synthesized by a microemulsion method. Ce0.8Er0.1Gd0.1O2-α-K2SO4-Li2SO4 composite electrolyte was prepared by mixing Ce0.8Er0.1Gd0.1O2-α powder with binary sulphates.
Wenbao Zhang +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source