Results 131 to 140 of about 14,831,698 (353)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Degree day models to forecast the seasonal phenology of Drosophila suzukii in tart cherry orchards in the Midwest U.S. [PDF]

PLoS One, 2020
Kamiyama MT, Bradford BZ, Groves RL, Guédot C.   +3 more
europepmc   +1 more source

Hobo Day Button, 1994

, 1994
Hobo Day button- purple and green background, purple and yellow lettering - Weary Wil wearing a safari hat and his dog spot - text reads 'Welcome to the Jungle! Hobo Day Safari, Oct.
Hobo Day Committee (South Dakota State University)
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Hobo Day Button, 1993

, 1993
Hobo Day button - orange and blue background, black and white lettering - Weary Wil wearing a mask and carrying a Trick of Treat! Bag - text reads 'Hobo Halloween, Hobo Day, SDSU vs.
Hobo Day Committee (South Dakota State University)
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Canada - Growing Degree-Days

, 1981
Contained within the 5th Edition (1978 to 1995) of the National Atlas of Canada is a map that shows the annual sum of normal degree-days above 5 C (an indicator of total heat available for plants in the growing season). Data for period 1941 to 1970.
openaire   +1 more source

Hobo Day Button, 1983

, 1983
Hobo Day button - blue background, yellow lettering - , Weary Wil leaning against the Coughlin Campanile text reads 'Hobo Day '83, A Hobo Odyssey, Oct. 15, SDSU vs.
Hobo Day Committee (South Dakota State University)
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Hedging irrigated maize crop yields using temperature derivatives in Malawi

Heliyon
Agriculture production yield varies with weather changes. This causes farmers incur loses. For instance, extreme temperature leads to low maize yield. This study describes incomplete temperature weather derivatives in agriculture markets and applies risk
Prince Blackson Dennis Chirwa, Nelson Christopher Dzupire   +1 more
doaj   +1 more source