Results 151 to 160 of about 14,831,698 (353)
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Hobo Day button - yellow background, green and blue lettering - heads of Weary Wil and Dirty Lil, and Spot the dog inside a lucky horseshoe, small UPC (University Programs Council) logo - text reads 'Luck of the Hobos, Hobo Day '05, October 22, SDSU ...
Hobo Day Committee (South Dakota State University)
core
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Hobo Day button - green and orange background, white, orange and blue lettering - heads of Weary Wil, Dirty Lil and Spot the dog riding a surf board - text reads "Hobos in Hawaii, Oct. 23, 1999, SDSU vs.
Hobo Day Committee (South Dakota State University)
core
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Hobo Day button - alternating blue and yellow for background and lettering - "South Dakota State College Jackrabbit mascot with NDU Sioux mascot tied to a pole - text reads ""South Dakota State College Hobo Day - Beat the Sioux Oct.
Hobo Day Committee (South Dakota State University)
core
CEACAM1 participation in breast cancer progression
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Hobo Day button - yellow and blue background, blue and white lettering, orange accents - Weary Wil and Dirty Lil wearing construction hats, Spot the Dog is on a sign, small UPC (University Programs Council) logo - text reads 'Hobos Under Construction ...
Hobo Day Committee (South Dakota State University)
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The effect of four host plant species [Mango, Mangifera indica L., Cinnamon, Cinnamomum cassia, Cashew, Anacardium occidentale L., Som, Machilus bombycina King], on biology of the polyphagous defoliator Cricula trifenestrata Helfer (Lepidoptera ...
S. K. Gharde, N. Chaudhuri
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