An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Watermelon response to plastic mulch and row covers
European Journal of Horticultural Science, 2006 L. Ibarra-Jiménez +4 more
doaj +1 more source
Climate, Prices, and Renovation in EU Household Energy Demand: End-Use Projections to 2050
EnergiesThis paper estimates end-use demand elasticities for European Union residential energy consumption and applies them to projections of household energy demand up to 2030 and 2050.
António Duarte Santos +1 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Cover crop mixture expression is influenced by nitrogen availability and growing degree days. [PDF]
PLoS One, 2020 Baraibar B +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Reproductive phenology of the Chesapeake Bay blue crab population in a changing climate
Frontiers in Ecology and EvolutionGlobal temperatures are rising across marine ecosystems in response to climate change. Marine and estuarine-dependent species including the blue crab, Callinectes sapidus, may adapt to warming temperatures phenologically, by shifting the seasonal timing ...
Alexandra K. Schneider +2 more
doaj +1 more source
Commentary on: Megyesi MS, Nawrocki SP, Haskell NH. Using accumulated degree-days to estimate the postmortem interval from decomposed human remains. J Forensic Sci. 2005;50(3):618-26. doi: 10.1520/JFS2004017; and Moffatt C, Simmons T, Lynch-Aird J. An improved equation for TBS and ADD: Establishing a reliable postmortem interval framework for casework and experimental studies. J Forensic Sci. 2016;61(Suppl 1):S201-S207. doi: 10.1111/1556-4029.12931. [PDF]
J Forensic Sci, 2023 Smith DH, Ehrett C, Weisensee K, Tica C.
europepmc +1 more source