Results 121 to 130 of about 4,447,300 (306)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
, 1981 Contained within the 5th Edition (1978 to 1995) of the National Atlas of Canada is a map that shows the annual sum of heating degree days (an indicator of building heating needs). Data for period 1941 to 1970. Companion sheet to Frost-Free Period, Growing Degree-Days, Last Frost in Spring and First Frost in Autumn.
openaire +1 more source
Thawing Degree Days over Hokkaido
Journal of the Japanese Society of Snow and Ice, 1961 The author calculated the thawing degree days (>0°C) over Hokkaido from the normals of daily mean temperature. Then, he drawed the isopleth of sum of thawing degree days at the end of every decades of month, counting from 1 st. January. As the normals are not satisfactory statistical data, for the purpose of planning various industries as well as flood
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Broad band polarimetric follow-up of Type IIP SN 2012aw
, 2014 We present the results based on R-band polarimetric follow-up observations of the nearby (~10 Mpc) Type II-plateau SN 2012aw. Starting from ~10 days after the SN explosion, these polarimetric observations cover ~90 days (during the plateau phase) and are
Eswaraiah, C. +3 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Assessment of Regional Residential Energy Performance Using Degree Days
BuildingsThis study proposes a climate-adjusted framework for evaluating regional residential energy performance by introducing Energy Consumption per Degree-Day (ECDD), an indicator that normalizes end-use energy consumption by climatic demand.
Akio Tanaka +2 more
doaj +1 more source
Freezing Degree Days over Hokkaido
Journal of the Japanese Society of Snow and Ice, 1962 The author calculated the freezing degree days (
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source