Results 121 to 130 of about 407,418 (293)

Dynamic Fragmentation Mechanism of High-altitude Rockfalls: An Experimental Study on Energy Conversion

工程科学与技术
ObjectivePrior to incorporating fragmentation into predictive trajectory models, further research is required to gain a comprehensive understanding of its impact.
HUANG Jian, YUAN Yuan, ZENG Tan, ZHOU Kun, YUAN Jingqing, LI Jingheng   +5 more
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

How degree of conversion and E-modulus of light-cure dental-resins interact [PDF]

, 2006
Objectives: To investigate how E-modulus, degree of conversion (DC%) and rate of polymerization of the most used monomer resins in dental light-cure composites interact. Methods: Young's modulus and DC% were studied for 21 different resin combinations of
Emami, Nazanin,, Söderholm, Karl-Johan M.   +1 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Influence of Polymerization Light Intensity on the Degree of Conversion of Composite Materials (Part I) [PDF]

, 2005
Stupanj konverzije kompozitnih materijala tijekom polimerizacije važan je čimbenik koji utječe na kakvoću i dugotrajnost kompozitnog ispuna. Osim sastava kompozitnoga materijala na stupanj konverzije uvelike utječu i značajke izvora svjetla za ...
Knežević, Alena, Zrinka Tarle, Ristić, Mira, Alajbeg, Iva, Alena Knežević, Iva Alajbeg, Mira Ristić, Tarle, Zrinka   +7 more
core   +1 more source

Comparative Insights Into the Degree of Conversion of a 3D‐Printed Photopolymer Occlusal Splint Resin Fabricated by Stereolithography and Masked Stereolithography Compared to Heat‐Polymerized Acrylics

Macromolecular Materials and Engineering
The degree of conversion (DC) is a critical determinant of the biocompatibility and long‐term performance of occlusal splints. However, limited evidence exists on how emerging three‐dimensional printing technologies, particularly masked stereolithography
Izim Turker Kader, Yurdanur Ucar, Pinar Kursoglu   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source