Results 161 to 170 of about 407,418 (293)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Effect of Additional Light Curing on Color Stability and Degree of Conversion of Mono-Shade Resin Composites. [PDF]

Polymers (Basel)
Bedir F, Karadaş M, Atıcı Bedir MG, Özdoğan A.   +3 more
europepmc   +1 more source

Evaluation of flexural strength, degree of conversion, and demineralization-prevention properties in adjacent tooth structures of an experimental fissure sealant containing nano-calcium-phosphate compounds. [PDF]

BMC Oral Health, 2023
Fallahzadeh F, Pirmoradian M, Ghasemi SM, Mortazavi M.   +3 more
europepmc   +1 more source

Styrene polymerization to high degrees of conversion

Polimery, 1981
STEFAN POLOWINSKI, SYLWIA TARKOWSKA
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The influence of salivary contamination during light curing on degree of conversion and color stability of two composite resins. [PDF]

J Oral Biol Craniofac Res
Rohaninasab M, Falahat S, Tayebi G, Manouchehri F, Mahounak FS.   +4 more
europepmc   +1 more source

Novel 1,2-Bismethacrylate-3-Eugenyl Propane for Resin Composites: Synthesis, Characterization, Rheological, and Degree of Conversion. [PDF]

Polymers (Basel), 2023
Al-Kahtani HM, Al-Odayni AB, Saeed WS, Robaian A, Al-Kahtani A, Aouak T, Alrahlah A.   +6 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Dual role of piperine: Preserving the degree of conversion of resin cement on bleached enamel and exhibiting antimicrobial activity. [PDF]

J Clin Exp Dent
de Flaviano Albuquerque TE, Aragão LR, Barbosa da Silva WM, Mota do Nascimento GH, Pinheiro SO, Marque Lima Rolim JP, Dias Frota de Carvalho BM, Cunha DA, Queiroz Pereira AÁ, Neri JR.   +9 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source