Results 91 to 100 of about 1,094 (190)
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2019 Exploration on anticancer candidates on inhibition of Heat Shock Protein (HSP) activity are increasing in the past ten years. Some of HSP90 inhibitor candidates were in third phase of clinical trials.
Rehmadanta Sitepu
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Cytotoxic effects of deguelin in cultured HNSCC cells.
, 2013 Hep-2 cells were exposed to deguelin at a various concentration (10, 25, 50, 100 and 200 µM) for 72 hours (A) or exposed to 100 µM of deguelin for different time points (12, 24, 48 and 72 hours) (B), cell viability was then measured by MTT assay.
Chun-cheng Lu (276392) +6 more
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PLoS ONE, 2015 Plants with pesticidal properties have been investigated for decades as alternatives to synthetics, but most progress has been shown in the laboratory. Consequently, research on pesticidal plants is failing to address gaps in our knowledge that constrain
Prisila Mkenda +5 more
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Viruses, 2019 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...]
Beatrice Mercorelli +4 more
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STUDIES TOWARD TOTAL SYNTHESIS OF (-)-DEGUELIN
, 2013 Deguelin, as a rotenoid, has emerged as an attractive pharmacophore for chemprevention due to its effectiveness for both in vitro and in vivo models.
Li, Bao
core
Deguelin downregulates AKT/NFκB mediated prosurvival signals in CLL cells.
, 2016 (A) PBMCs from 3 CLL patients were treated for 24h with 0, 10, or 100 μM deguelin. Viability was evaluated by flow cytometry after Annexin V/IP staining. Figure shows immunoreactive bands for several deguelin target molecules and β-actin in western blots
Silvia Rosado (39145) +9 more
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Deguelin gavage is well tolerated.
, 2013 Bodyweight is determined before and after Deguelin treatment. The gain in bodyweight is a sign for good tolerance of the substance. The graph represents the increases in bodyweight vs. weight at begin of the experiment.
Bertram Scheller (318724) +8 more
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, 2018 Deguelin, a rotenoid, is isolated from a natural plant species, and has biological activities including antitumor function. In the present study, we investigated the effect of deguelin on the cell adhesion, migration and invasion of NCI-H292 human lung ...
Jaw-Chyun Chen +8 more
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Pharmacological inhibition of PI3K/AKT activity by deguelin to treat oral cancers
, 2007 魚藤素(deguelin)是一種非常具有發展潛力，可以抵抗癌症細胞生長的天然合成藥物。其主要機制在於抑制細胞AKT 蛋白的活性，在許多癌細胞種類中已經被證明AKT 蛋白都有過度活化的情況，如支氣管上皮細胞癌、結腸癌、急性骨髓白血病(acute myeloid leukemia，AML)、非小細胞肺癌(NSCLC)、乳癌以及皮膚鱗狀細胞(cutaneous squamous cell)，在使用魚藤素治療後具有很好的抑 癌功效。但是在口腔癌治療研究中則未被證實有任何功能以及在口腔癌中p ...
江耿男, Chiang, Geng-Nan
core
AMPK-dependent autophagy pathway contributes to deguelin-induced Hep-2 cell death.
, 2013 Hep-2 cells were pretreated with Z-VAD-fmk (50 µM) or 3-MA (2 mM) for 1 hr before deguelin exposure for 72 hours, cell viability was measured by MTT assay (A).
Chun-cheng Lu (276392) +6 more
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