Results 61 to 70 of about 1,195 (187)

Ethnomedicinal Practices of the Fabaceae Family in Tanzania: A Systematic Review

The Scientific World Journal, Volume 2026, Issue 1, 2026.
This study is aimed at reviewing the ethnomedicinal, phytochemical and pharmacological properties of Fabaceae species used as sources of traditional medications in Tanzania. Using the Systematic Reviews and Meta‐Analyses (PRISMA) methodology, a comprehensive review was conducted on Fabaceae species used by Tanzanians through electronic databases such ...
David Sylvester Kacholi, Kalyani Sen
wiley   +1 more source

Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine. [PDF]

PLoS ONE, 2015
Oral cancer is one of the main causes of cancer-related deaths in South-Asian countries. There are very limited treatment options available for oral cancer.
Saurabh Bundela, Anjana Sharma, Prakash S Bisen   +2 more
doaj   +1 more source

GC-MS analysis of bioactive phytochemicals from methanolic leaf and root extracts of Tephrosia vogelii

Scientific African, 2022
The objective of this study was to determine the phytochemical compounds present in methanolic root and leaf extracts of Tephrosia vogelii. The plant species is found in the genus Tephrosia and family Fabaceae.
Stephano Hanolo Mlozi, Juma A. Mmongoyo, Musa Chacha   +2 more
doaj   +1 more source

Concise Total Synthesis of (±)-Deguelin and (±)-Tephrosin Using a Vinyl Iodide as a Key Building Block

, 2018
A concise and protecting-group-free total synthesis of the antiproliferative natural product (±)-deguelin (2) was accomplished in four steps and 62% overall yield from commercially available precursors.
Shengtao Xu (513564), Guangyu Wang (553563), Aijun Lin (1393531), Jinyi Xu (1748593), Wenlong Li (571749), Hequan Yao (1393537), Feijie Xu (4852714)   +6 more
core   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Guidance on the use of read‐across for chemical safety assessment in food and feed

EFSA Journal, Volume 23, Issue 7, July 2025.
Abstract Read‐across is a method used in chemical risk assessment to predict the toxicological properties of a target substance by using data from structurally and mechanistically similar substances, known as source substances. EFSA's Scientific Committee has developed an approach for using read‐across in food and feed risk assessment.
EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Pikka Jokelainen, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Edoardo Villa, Holger Zorn, Emilio Benfenati, Romualdo Benigni, Qasim Chaudhry, Lucian Farcal, George Kass, Alexis Nathanail, Alicia Paini, Rositsa Serafimova   +26 more
wiley   +1 more source

Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer

Oncology Reports, 2010
Gastric cancer is often diagnosed in locally advanced or metastatic stages, which preludes a poor prognosis. As only 10% of patients with advanced gastric cancer treated with chemotherapy survive 2 years, new approaches for preventing and controlling the disease are required. We therefore, assessed in gastric cancer cells the chemotherapeutic potential
Hyunseung, Lee, Ju-Hee, Lee, Kyung Hee, Jung, Soon-Sun, Hong   +3 more
openaire   +3 more sources

Biosynthesis and Characterization of Ag3PO4/SnO2 Nanocomposites for Effective Photocatalytic Degradation of Rhodamine B and Biological Applications

Journal of Nanotechnology, Volume 2025, Issue 1, 2025.
The current investigation focuses on the photocatalytic degradation and biological applications of M. sericea leaf extract‐mediated Ag3PO4/SnO2 nanocomposites (NCs). The synthesized nanomaterials were characterized through various characterization techniques to determine their structural and optical properties.
Vrushali Manoj Hadkar, Selvaraj Mohana Roopan, Chinnadurai Immanuel Selvaraj, Sivakumar Manickam   +3 more
wiley   +1 more source

Transglutaminase 3 regulates cutaneous squamous carcinoma differentiation and inhibits progression via PI3K-AKT signaling pathway-mediated Keratin 14 degradation. [PDF]

Cell Death Dis
Cutaneous squamous carcinoma is the second most common epithelial malignancy, associated with significant morbidity, mortality, and economic burden. However, the mechanisms underlying cSCC remain poorly understood.
Zhou K, Wu C, Cheng W, Zhang B, Wei R, Cheng D, Li Y, Cao Y, Zhang W, Yao Z, Zhang X.   +10 more
europepmc   +2 more sources

A Novel Lysosome‐Related Gene Signature Predicts Lung Cancer Prognosis: A Bioinformatics‐Driven Study

Health Science Reports, Volume 7, Issue 12, December 2024.
ABSTRACT Background and Aims The biological function of lysosomes has been increasingly appreciated in cancer. However, the relationship between lysosome and lung adenocarcinoma (LUAD) was not well understood. In this study, a lysosome‐related signature was developed for LUAD risk stratification and prognosis prediction.
Wei Ye, Lin Sun, Cong Fu, Huajie Dong, Tong Zhou   +4 more
wiley   +1 more source