Results 41 to 50 of about 1,195 (187)

In Silico Research of New Therapeutics Rotenoids Derivatives against Leishmania amazonensis Infection

Biology, 2022
Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical knowledge of natural compounds and the latest bioinformatics advances to ...
Adrián Vicente-Barrueco, Ángel Carlos Román, Trinidad Ruiz-Téllez, Francisco Centeno   +3 more
doaj   +1 more source

Erratum: Corrigendum: Deguelin promotes longevity and healthspan through <i>C. elegans fmo-4</i>. [PDF]

MicroPubl Biol
europepmc   +2 more sources

Targeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis. [PDF]

Cell Death Dis
Radioresistance is a major constraint on the efficacy of lung cancer radiotherapy, but its mechanism has not been fully elucidated. Here, we found that FBXO22 was aberrantly highly expressed in lung cancer and that FBXO22 knockdown increased the ...
Chen Y, Zhou Y, Feng X, Wu Z, Yang Y, Rao X, Zhou R, Meng R, Dong X, Xu S, Zhang S, Wu G, Jie X.   +12 more
europepmc   +2 more sources

Larvicidal Activity of Isoflavonoids from Extracts Against

Natural Product Communications, 2012
The biological activity of extracts from the leaves, bark and roots of Muellera frutescens , an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides.
Charlotte Nirma, Alice M S. Rodrigues, Charlie Basset, Lionel Chevolot, Romain Girod, Christian Moretti, Didier Stien, Isabelle Dusfour, Véronique Eparvier   +8 more
doaj   +1 more source

The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts

Viruses, 2018
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus for which there is no vaccine or cure. This viral infection, once acquired, is life-long, residing latently in hematopoietic cells.
Masatoshi Nukui, Christine M. O’Connor, Eain A. Murphy   +2 more
doaj   +1 more source

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target

Biomedicines, 2020
Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment ...
Sung-Jun Hong, Jin-Tae Kim, Su-Jung Kim, Nam-Chul Cho, Kyeojin Kim, Seungbeom Lee, Young-Ger Suh, Kyung-Cho Cho, Kwang Pyo Kim, Young-Joon Surh   +9 more
doaj   +1 more source

Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain

, 2017
Deguelin exerts potent nematocidal activity via the mitochondrial respiratory ...
ND Young (9874463), M Cornaglia (13632082), A Hofmann (13531048), A Jabbar (11009766), S Preston (11009760), PW Sternberg (14533859), L Mouchiroud (13632079), BRE Ansell (14533847), PK Korhonen (14533844), KT Andrews (14533853), BCH Chang (23211), S Crawford (9864932), Sean Mcgee (13095276), MAM Gijs (14533856), RB Gasser (9888092), J Auwerx (13632103), RA Davis (14446038), C Nowell (13632085), GM Fisher (14533850), J Baell (13632106)   +19 more
core   +3 more sources

Plants in the Genus Tephrosia: Valuable Resources for Botanical Insecticides

Insects, 2020
Synthetic insecticides are effective in controlling insect pests but can also harm nontarget organisms and the environment. During the last 40 years, there has been an increasing interest in alternative insecticides, particularly those derived from ...
Peiwen Zhang, Deqiang Qin, Jianjun Chen, Zhixiang Zhang   +3 more
doaj   +1 more source

Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling

, 2017
Background. Deguelin has both antiproliferation and antimetastasis activities. However, high-dose deguelin elicits many undesired side effects. The purpose of this study was to investigate whether the low-dose deguelin can prevent the metastasis of oral ...
林思洸;郭彥彬, Liu, Yu-Peng;Lee, Jih-Jong;Lai, Tsung-Ching;Lee, Chien-Hsin;Hsiao, Ya-Wen;Chen, Po-Shen;Liu, Wei-Ting;Hong, Chi-Yuan;Lin, Se-Kwan;Kuo, Mark-Yen Ping;Lu, Pei-Jung;Hsiao, Michael   +1 more
core   +1 more source

Chemotherapeutic potential of deguelin and evaluation of new agents for skin cancer chemoprevention.

, 2003
Chemotherapeutic potential of deguelin and evaluation of new agents for skin cancer ...
Joell Janette. Gills (7986656)
core   +5 more sources