Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
PLoS ONE, 2013 BackgroundTreatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have shown significant success in steroid receptor positive or Her-2+ breast cancers respectively.
Rajeshwari Mehta +7 more
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Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin [PDF]
International Journal of Molecular Sciences, 2016 Pancreatic cancer is the fourth most common cause of cancer mortality worldwide. Furthermore, patients with pancreatic cancer experience limited benefit from current chemotherapeutic approaches because of drug resistance. Therefore, an effective therapeutic strategy for patients with pancreatic cancer is urgently required.
Xiao-Dong Xu +12 more
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Inhibition of adenovirus transport from the endosome to the cell nucleus by rotenone. [PDF]
Front Pharmacol, 2023 Regardless of the clinical impact of human adenovirus (HAdV) infections in the healthy population and its high morbidity in immunosuppressed patients, a specific treatment is still not yet available.
Balsera-Manzanero M +8 more
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Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells
International Journal of Hematology, 2009 The aim of the study was to investigate the anticancer effects and the molecular mechanisms of deguelin on Jurkat cells. Cell viability was assessed by MTT assay. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assay and transmission electron microscopy were used to detect cell apoptosis.
Shu, W-X +4 more
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Prediction of new C-terminal Hsp90 inhibitors based on deguelin scaffold: homology modeling, virtual screening, QM/MM docking, MM/GBSA, and molecular dynamics simulations. [PDF]
Res Pharm SciBackground and purpose: The N-terminal Hsp90 inhibitors are promising targets for cancer treatment; however, inducing the heat shock response is one of the most significant limitations.
Abbasi M, Talaei S, Farshidfar G.
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Deguelin inhibits perineural invasion in esophageal squamous cell carcinoma via targeting BDNF/TrkB axis. [PDF]
Cancer Biol TherBackground Perineural invasion (PNI) represents a uniquely distinctive pathway for tumor metastasis, but its underlying molecular mechanisms and therapy remain unclear.Methods Bioinformatics analysis and transcriptomic sequencing were first employed to ...
Wei Q +7 more
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Inhibitory Effects of B-, C-, and E-Ring-Truncated Deguelin Derivatives Against A549, HCT116, and MCF-7 Cancer Cells. [PDF]
ACS Omega, 2023 Francisco JAP, Paderes MC.
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BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells. [PDF]
PLoS ONE, 2016 This study has been undertaken to explore the therapeutic effects of deguelin and specific siRNAs in HeLa cells. The data provided clearly show the silencing of ERK 1/2 with siRNAs and inhibition of ERK1/2 with deguelin treatment in HeLa cells ...
Samra Hafeez +15 more
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Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice. [PDF]
Gut MicrobesAcetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear.
Gong S +18 more
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[Effect of deguelin on expression of nup98 in K562 cells].
Zhongguo shi yan xue ye xue za zhi, 2007 The study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98) in leukemia K562 cells. MTT assay was used to assess the effects of deguelin on cell proliferation. FCM and RT-PCR were used to analyze the changes of nup98 mRNA and protein in K562 cells after treating with deguelin.
Qiu-Ling, Wu +3 more
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