Deguelin's Anticancer Bioactivity: Challenges and Opportunities in Medicinal Chemistry. [PDF]
Front PharmacolDeguelin is a natural isoflavone derived from the rotenone family, commonly found in plants belonging to the Derris and Grifola genera. Comprehensive research has underscored its considerable promise in oncological treatment. Deguelin demonstrates anticancer activity by suppressing cell proliferation and promoting apoptosis via the modulation of ...
Jiang W, Zeng J, Guo L, Shi J, Lei Y.
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Stereocontrolled semi-syntheses of deguelin and tephrosin [PDF]
Organic & Biomolecular Chemistry, 2017 We describe stereocontrolled semi-syntheses of deguelin and tephrosin, anti-cancer rotenoids isolated from Tephrosia vogelii .
Russell, David A +4 more
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Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat. [PDF]
PLoS ONE, 2012 The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target.
Patrick Paulus +8 more
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Deguelin Restores Paclitaxel Sensitivity in Paclitaxel-Resistant Ovarian Cancer Cells via Inhibition of the EGFR Signaling Pathway. [PDF]
Cancer Manag ResSeunghee Bae,1 Sowon Bae,1 Hee Su Kim,1 Ye Jin Lim,1 Gyeongmi Kim,2 In-Chul Park,2 Kyeong A So,3 Tae Jin Kim,3 Jae Ho Lee1 1Department of Cosmetics Engineering, Konkuk University, Seoul, 05029, Republic of Korea; 2Division of Fusion Radiology Research ...
Bae S +8 more
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Antiangiogenic Effect of Deguelin on Choroidal Neovascularization
The Journal of Pharmacology and Experimental Therapeutics, 2008 Age-related macular degeneration is the leading cause of blindness in the elderly. Choroidal neovascularization (CNV) leads to severe vision loss in patients of age-related macular degeneration. Previously, we have demonstrated that deguelin, isolated from plants in the Mundulea sericea family, is a chemopreventive agent.
Jeong Hun, Kim +6 more
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Akt inhibitor deguelin aggravates inflammation and fibrosis in myocarditis. [PDF]
Iranian journal of basic medical sciences, 2019 Myocarditis is characterized by inflammatory cell infiltration in myocardial stroma. Attenuation of tumor necrosis factor (TNF)-α and interleukin (IL)-1β is a reliable mark for improving the prognosis. Protein kinase B (Akt) plays an important role in the development and progression of myocarditis.
Li, Shanshan +10 more
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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway [PDF]
Acta PharmaceuticaDeguelin exhibits antiproliferative activity against various cancer cell types. Previous studies have reported that deguelin exhibits pro-apoptotic activity against human cancer cells. The current study aimed at further elaborating the anticancer effects
Sun Kening +4 more
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Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells. [PDF]
PLoS ONE, 2013 Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States and around the world. Despite advances in the management of patients with this disease, the survival has not been significantly ...
Yan-li Yang +6 more
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EBioMedicine, 2017 Aurora B kinase has emerged as a key regulator of mitosis and deregulation of Aurora B activity is closely related to the development and progression of human cancers.
Xinfang Yu +5 more
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Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway
Cancer Management and Research, 2018 Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Yuan,1,4 Qian Xiao,1,2 Kefeng Ding1,2 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key ...
Chen L +8 more
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