Results 51 to 60 of about 6,220 (165)

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Transient exposure to environmentally realistic concentrations of di-(2-ethylhexyl)-phthalate during sensitive windows of development impaired larval survival and reproduction success in Japanese medaka

Toxicology Reports, 2020
Di-(2-ethylhexyl) phthalate (DEHP) is a well-known endocrine disruptor and it is ubiquitously distributed in the environment. However, very few studies have investigated the effects of short-term exposure to environmentally realistic concentrations of ...
Bonny Bun Ho Yuen, Anna Boya Qiu, Bruce Hao Chen   +2 more
doaj   +1 more source

Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life

Frontiers in Endocrinology, 2023
IntroductionDEHP is an endocrine disruptor widely used in the production of malleable plastics. DEHP exposure was associated with altered hypothalamic-pituitary-thyroid (HPT) axis function.
Érica Kássia Sousa-Vidal, Guilherme Henrique, Renata Elen Costa da Silva, Caroline Serrano-Nascimento, Caroline Serrano-Nascimento, Caroline Serrano-Nascimento   +5 more
doaj   +1 more source

Bisphenols and Phthalates in Bottled Mineral Water: First Evidence of Co‐Occurrence, Estrogenic Activity, and Health Risk in Brazil

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), its structural analogs, and phthalates are synthetic chemicals widely used, with documented endocrine‐disrupting activity. This study aimed to develop and validate a selective multiresidue analytical method for the simultaneous determination of BPA, 10 bisphenol analogs, and six phthalates in PET‐bottled mineral water.
Giulia Boito Reyes, Lucas Correia Gonçalves, Fernanda Cristina Iba Molinari, José Eduardo Gonçalves   +3 more
wiley   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

Equine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez, Alejandro de la Fuente, Kazuki Takahashi, Hugo Monteiro, Mauricio Mendes, Stuart Meyers, Pouya Dini   +6 more
wiley   +1 more source

DEHP exposure destroys blood-testis barrier (BTB) integrity of immature testes through excessive ROS-mediated autophagy

Genes and Diseases, 2018
Di-(2-ethylhexyl) phthalate (DEHP), is known to impair testicular functions and reproduction. However, its effects on immature testis Blood-testis barrier (BTB) and the underlying mechanisms remain obscure.
W.E.I. Yi, Tang Xiang-Liang, Zhou Yu, Liu Bin, Shen Lian-Ju, Long Chun-lan, L.I.N. Tao, H.E. Da-wei, W.U. Sheng-de, W.E.I. Guang-hui   +9 more
doaj   +1 more source

Development and production of allogeneic cord blood‐derived red blood cell concentrates for transfusion to extremely preterm neonates, the All‐Cord study

Transfusion, EarlyView.
Abstract Background Extremely preterm neonates often require red blood cell (RBC) transfusions derived from adult donors. These transfusions introduce adult hemoglobin into a neonatal hematopoietic system dominated by fetal hemoglobin (HbF), shifting the oxygen‐dissociation curve and increasing oxygen delivery to immature tissues.
Jip H. van Daelen, Joyce Bestebroer, Herbert Korsten, Christie Vermeulen, Irwin K. M. Reiss, Enrico Lopriore, Pauline M. Snijder, Elise J. Huisman, Thomas R. L. Klei   +8 more
wiley   +1 more source

Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma

Ecotoxicology and Environmental Safety
Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP is easily leached out to the environment due to the lack of covalent bonds with plastic. High dose of DEHP exposure is often observed in hemodialysis patients because
Ming-Syuan Shih, Fat-Moon Suk, Wan-Chun Chiu, Chun-Ya Lee, Fang-Yu Hsu, Yi-Jen Liao   +5 more
doaj   +1 more source

Direct and transgenerational effects of low doses of perinatal di-(2-ethylhexyl) phthalate (DEHP) on social behaviors in mice. [PDF]

PLoS ONE, 2017
Di-(2-ethylhexyl) phthalate (DEHP) is an endocrine disrupting chemical commonly used as a plasticizer in medical equipment, food packaging, flooring, and children's toys.
Kayla M Quinnies, Erin P Harris, Rodney W Snyder, Susan S Sumner, Emilie F Rissman   +4 more
doaj   +1 more source

Bacterial proliferation is comparable in red blood cell concentrates stored in DEHT/PAGGSM and DEHP/SAGM containers

Vox Sanguinis, EarlyView.
Abstract Background and Objectives The European Union's ban on the use of di(2‐ethylhexyl) phthalate (DEHP) in medical devices will take effect in 2030. DEHP is a plasticizer in polyvinyl chloride blood bags that helps stabilize the red blood cell membrane during hypothermic red blood cell concentrate (RBCC) storage.
Sandra Ramirez‐Arcos, Yuntong Kou, Dilini Kumaran, Geraldine M. Walsh, Anita Howell, Chryslain Sumian, Stefan Reichenberg, Quentin Brebant, Ken McTaggart   +8 more
wiley   +1 more source