Results 51 to 60 of about 23,764 (211)

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Stability of Glutamate-Aspartate Cardioplegia Additive Solution in Polyolefin IV Bags [PDF]

, 2015
Objective: Glutamate-aspartate cardioplegia additive solution (GACAS) is used to enhance myocardial preservation and left ventricular function during some cardiac surgeries.
Ciancaglini, Peter P., Gilbert, Justine M., Hughes, Susan E., Kim, Stephanie E., Rush, Steven D., Zhao, Fang   +5 more
core   +2 more sources

Lycopene prevents DEHP-induced Leydig cell damage with the Nrf2 antioxidant signaling pathway in mice.

Journal of Agricultural and Food Chemistry, 2019
As a plasticizer, di(2-ethylhexyl) phthalate (DEHP) is the most usually used phthalates. Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and masculinization by androgens of synthesis and secretion.
Yi Zhao, Mu Li, Yue Shen, Jia Lin, Hao-Ran Wang, M. Talukder, Jin-Long Li   +6 more
semanticscholar   +1 more source

Exposure of patients to di(2-ethylhexy)phthalate (DEHP) and its metabolite MEHP during extracorporeal membrane oxygenation (ECMO) therapy

PLoS ONE, 2020
The plasticizer di(2-ethylhexyl)phthalate (DEHP) is often used for PVC medical devices, that are also largely used for intensive care medical treatments, like extracorporeal membrane oxygenation (ECMO) therapy. Due to the toxicological potential of DEHP,
F. Kaestner, F. Seiler, Daniel Rapp, Elisabeth Eckert, J. Müller, C. Metz, R. Bals, H. Drexler, P. Lepper, T. Göen   +9 more
semanticscholar   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

Endocrine disruptors in bottled mineral water : total estrogenic burden and migration from plastic bottles [PDF]

, 2009
Background, aim, and scope Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g ...
Oehlmann, Jörg, Wagner, Martin
core   +1 more source

Di-(2-ethylhexyl) phthalate (DEHP) inhibits steroidogenesis and induces mitochondria-ROS mediated apoptosis in rat ovarian granulosa cells.

Toxicological Research, 2019
Increased oxidative stress (OS) due to ubiquitous exposure to di-(2-ethylhexyl) phthalate (DEHP) can affect the quality of oocytes by inducing apoptosis and hampering granulosa cell mediated steroidogenesis.
A. Tripathi, V. Pandey, A. Sahu, A. Singh, P. Dubey   +4 more
semanticscholar   +1 more source

Physico‐Chemical Understanding of Plasticizers Interaction with P(VDF‐TrFE‐CFE) Electroactive Polymer

Macromolecular Materials and Engineering, EarlyView.
This study explores the effects of DNOP plasticizer on P(VDF‐TrFE‐CFE) terpolymers, revealing a strong synergy between chemical structure and physical properties. High TrFE bringing natural flexibility and CFE enhancing the plasticizer retention through theorized halogen bonds, ultra‐soft, crack‐free films of high permittivity and softness are ...
Colin Lesenne, David Audigier, Jean‐Fabien Capsal   +2 more
wiley   +1 more source

Reproductive and developmental effects of phthalate diesters in females. [PDF]

, 2013
Phthalate diesters, widely used in flexible plastics and consumer products, have become prevalent contaminants in the environment. Human exposure is ubiquitous and higher phthalate metabolite concentrations documented in patients using medications with ...
Chambers, Christina, Foster, Warren G, Kay, Vanessa R   +2 more
core   +1 more source