Results 11 to 20 of about 276 (148)
Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites. [PDF]
J Steroid Biochem Mol Biol, 2021 7-Dehydrocholesterol reductase (DHCR7) catalyses the final step of cholesterol biosynthesis in the Kandutsch-Russel pathway, the reduction of 7-dehydrocholesterol (7DHC) to cholesterol. 7DHC can be acted on by a range of other enzymes including CYP27A1 and CYP11A1, as well as by UVB radiation, producing a number of derivatives including hydroxy ...
Tuckey RC +3 more
europepmc +3 more sources
Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey. [PDF]
Molecules, 2020 20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP11A1 also hydroxylates D3 to 22-monohydroxyvitamin D3 (22(OH)D3), which is detectable in the epidermis ...
Kim TK +6 more
europepmc +5 more sources
Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. [PDF]
Org Biomol Chem, 2015 We report here that H-atom tunneling facilitates the propagation step in the tocopherol-mediated peroxidation (TMP) of 7-dehydrocholesterol. This process likely becomes a major propagation pathway when radical intermediates are isolated in cellular organelles or lipid particles such as low-density lipoproteins.
Muchalski H, Xu L, Porter NA.
europepmc +4 more sources
7-Dehydrocholesterol dictates ferroptosis sensitivity. [PDF]
NatureFerroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid peroxidation, has been implicated in multiple diseases, including cancer1-3, degenerative disorders4 and organ ischaemia-reperfusion injury (IRI)5,6. Here, using genome-wide CRISPR-Cas9 screening, we identified that the enzymes involved in distal cholesterol ...
Li Y +24 more
europepmc +3 more sources
Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol. [PDF]
J NanobiotechnologyAbstract Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge. Methods We explore an approach that enables ferroptosis induction through ...
Li J +17 more
europepmc +4 more sources
Journal of Lipid Research, 1967 Chromatographic methods for the separation of 24- and 25-dehydrocholesterols are described. The purities of three commercial samples of 24-dehydrocholesterol examined by thin-layer and gas-liquid chromatography were only 42, 79, and 80%, respectively; a ...
James A. Svoboda, Malcolm J. Thompson
doaj +1 more source
A New Route to 7-Dehydrocholesterol, Provitamin D3 [PDF]
Nature, 1946 IN 1935, Windaus, Lettre and Schenck1 described the preparation from cholesterol (I) of 7-dehydrocholesterol (III), which on irradiation gave a highly antirachitic product (vitamin D3), later2 shown to be identical with the naturally occurring vitamin D isolated from tunny liver oil.
H. B. HENBEST +4 more
openaire +2 more sources
Taiwanese Journal of Obstetrics & Gynecology, 2017 Objective: To show the importance of measuring cholesterol precursor levels in amniotic fluid in all pregnancies with ultrasound features (such as holoprosencephaly) suggestive of Smith–Lemli–Opitz syndrome (SLOS), after exclusion of chromosomal ...
André Travessa +3 more
doaj +1 more source
Biosynthesis of Pregnenolone from Cholesterol by Mitochondrial Enzymes of Bovine Adrenal Cortex [PDF]
, 1978 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66357/1/j.1432-1033.1978.tb20931.x ...
Koizumi, Naoyuki +4 more
core +1 more source
Пороки развития кистей и стоп при синдроме Смита - Лемли - Опитца [PDF]
, 2013 Smith-Lemli-Opitz syndrome is rare genetic disorder with multiple limb malformations and neurological manifestation, caused by inborn defect of cholesterol metabolism.
Kenis V.M. +2 more
core +2 more sources